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Aligned relations for Sodium Channel:
X-Relation-Y Y-Relation-Z
Lithium INHIBITS Sodium Channel Correct? #Y/N
CONCLUSIONS: The widely used drug lithium is a potent blocker of cardiac sodium channels and may unmask patients with the Brugada syndrome. (PMID: 16144991) 0/0
Because lithium is a potent blocker of cardiac sodium channels , and given the critical importance of sodium channels in pacemaker activity, lithium-induced sodium channel blockade is likely an important mechanism in sinus node dysfunction. (PMID: 17347696) 0/0
Lithium inhibits function of voltage-dependent sodium channels and catecholamine secretion independent of glycogen synthase kinase-3 in adrenal chromaffin cells. (PMID: 17950380) 0/0
Lithium can unmask Brugada syndrome through its ability to block sodium channels , even at subtherapeutic concentrations. (PMID: 20016437) 0/0
Sodium Channel ASSOCIATED_WITH Brugada syndrome Correct? #Y/N
These results demonstrate that the disruption of SCN5A cell-surface localization is one mechanism that can account for the loss of functional sodium channels in Brugada syndrome . (PMID: 11420310) 0/0
Mutations in SCN5A, a cardiac sodium channel gene, have been recently associated with Brugada syndrome . (PMID: 11960580) 0/0
A cardiac sodium channel mutation identified in Brugada syndrome associated with atrial standstill. (PMID: 14687250) 0/0
Compound heterozygous mutations P336L and I1660V in the human cardiac sodium channel associated with the Brugada syndrome . (PMID: 17075016) 0/0
Loss-of-function mutations in SCN5A, the gene encoding the cardiac sodium channel , are linked to Brugada syndrome (BrS). (PMID: 20390067) 0/0
Molecular study did not reveal the same mutations in the cardiac sodium channel gene (SCN5A) as previously reported in Brugada syndrome . (PMID: 11155778) 0/0
BACKGROUND: Brugada syndrome (BrS) primarily associates with the loss of sodium channel function. (PMID: 24352520) 0/0
We aimed to study whether mutations in the beta-subunits of sodium channel (SCN1B and SCN2B) would also be associated with abnormal cardiac excitation in BrS . (PMID: 20137763) 0/0
Sodium Channel CAUSES Brugada syndrome Correct? #Y/N
Changes in the sodium channel are responsible for long QT syndrome, Brugada syndrome and conduction defects. (PMID: 17497250) 0/0
INTRODUCTION: Loss-of-function mutations in the SCN5A gene encoding the cardiac sodium channel are responsible for Brugada syndrome (BS) and also for progressive cardiac conduction disease (inherited Lenegre disease). (PMID: 16643399) 0/0
Indeed, dysfunctional sodium channels have been shown to be responsible for several inherited cardiac electrical disorders, such as Long QT and Brugada syndromes (BrS), potentially leading to fatal arrhythmic events. (PMID: 17504259) 0/0
Because of its effect on the resting membrane potential, reduction or increase of TRPM4 channel function may both reduce the availability of sodium channel and thus lead to BrS . (PMID: 23382873) 0/0
A novel missense mutation, I890T, in the pore region of cardiac sodium channel causes Brugada syndrome . (PMID: 23308164) 0/0
Loss of function mutations in SCN5A, encoding the cardiac sodium channel , are one cause of the Brugada syndrome , associated with slow conduction and a high incidence of ventricular fibrillation, especially in Asians. (PMID: 16415376) 0/0
Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease. (PMID: 16877553) 0/0
Mutations of SCN5A, gene-encoding alpha-subunit of cardiac sodium channel , can cause mixed phenotypes of Brugada syndrome (BrS) and cardiac conduction diseases (CCD). (PMID: 19719504) 0/0
Sodium Channel PREDISPOSES Brugada syndrome Correct? #Y/N
A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families. (PMID: 15910881) 0/0
Sodium Channel NEG_ASSOCIATED_WITH Brugada syndrome Correct? #Y/N
CONCLUSION: Our experimental and computational analysis of the E161K mutation suggests that a loss of sodium channel function is not only associated with Brugada syndrome and conduction disease, but may also cause sinus node dysfunction in carriers of this mutation. (PMID: 15910881) 0/0