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X-Relation-Y Y-Relation-Z
Lithium INTERACTS_WITH Genes Correct? #Y/N
Differential display PCR was used to identify genes regulated by mood stabilizer lithium in rat cerebral cortex. (PMID: 10381544) 0/0
None of these genes were regulated by lithium in healthy control subjects. (PMID: 14735134) 0/0
In view of the wider clinical applications, it is necessary to examine alterations in levels of expression of genes affected by lithium. (PMID: 21547488) 0/0
We identified 44 and 416 genes that were regulated by lithium and valproate, respectively. (PMID: 19949822) 0/0
The discussed targets represent part of genes altered by chronic lithium. (PMID: 23324999) 0/0
At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. (PMID: 23619527) 0/0
Given the substantial evidence for the role of inositol in the mechanism of action of lithium and valproate. the opposing and mild effects of lithium on the genes encoding inositol monophosphatase in yeast and human cells, but the powerful effect of lithium and valproate on INO1 in yeast, it is hypothesized that human hIANO1 is a factor in the psychopharmacology of mood stabilizers. (PMID: 12479670) 0/0
To examine whether lithium affects the expression of genes regulating the circadian clock, cultured NIH-3T3 cells were synchronized by serum-shocking, and the relative expression of the clock genes Period1 (Per1), Period2 (Per2), Period3 (Per3), Cryptochrome1 (Cry1), Cryptochrome2 (Cry2), Brain and muscle aryl hydrocarbon nuclear translocator-like 1 (Bmal1), Circadian locomotor output cycles kaput (Clock), Rev-Erb-alpha (Nr1d1), RAR-related orphan receptor alpha (Ror-alpha), Glycogen synthase kinase-3beta (Gsk-3beta), Casein kinase 1-epsilon (CK1-epsilon; Csnk1epsilon), E4 binding protein 4 (E4BP4; Nfil-3) and albumin D-binding protein (Dbp) was examined for three consecutive days in the presence of lithium (20 mM) or vehicle (20 mM NaCl). (PMID: 20837565) 0/0
Lithium INTERACTS_WITH FOS|FOS gene Correct? #Y/N
We find that lithium , at therapeutic doses, has an augmenting effect on phosphatidylinositol (PI)-mediated fos expression induced by activating a muscarinic cholinergic pathway, whereas it has no effect, at tenfold the therapeutic dose, on fos expression induced by receptor or postreceptor activators of cyclic adenosine monophosphate (cAMP). (PMID: 1674966) 0/0
In addition, the time-course and persistence of the effect of chronic lithium on 5-HT2A/2C receptor-mediated Fos expression was examined. (PMID: 9681934) 0/0
The results of the time-course experiment demonstrated that the enhancing effect of lithium on 5-HT2A/2C receptor-mediated Fos expression was short-lived such that Fos-like immunoreactivity returned to untreated levels within 48 h. (PMID: 9681934) 0/0
The effect of lithium on methamphetamine-induced regional Fos protein expression in the rat brain. (PMID: 10321456) 0/0
Differential effect of lithium on fos protooncogene expression mediated by receptor and postreceptor activators of protein kinase C and cyclic adenosine monophosphate: model for its antimanic action. (PMID: 1674966) 0/0
Lithium INHIBITS APP|APP gene Correct? #Y/N
Moreover, oral administration of lithium significantly reduces Abeta production whereas direct ICV administration of roscovitine augmented Abeta production in the brains of PDAPP (APP(V717F)) mice. (PMID: 14651959) 0/0
Evidence supporting this hypothesis suggests that lithium decreases Abeta peptide production and inhibits the activity of glycogen synthase kinase-3 which induces aggregation of tau protein into tangles, and tau hyperphosphorylation. (PMID: 18760542) 0/0
AChE infusion into rat hippocampus determines the appearance of anti-Abeta and thioflavine-S positive plaques, and AChE-Abeta toxicity on hippocampal cultures was blocked by lithium, an activator of the Wnt cascade. (PMID: 11261806) 0/0
Lithium is known to be neuroprotective in various models of neurodegenerative disease, and can reduce Abeta generation by modulating glycogen synthase kinase-3 (GSK-3) activity. (PMID: 22583494) 0/0
Lithium STIMULATES FOS|FOS gene Correct? #Y/N
The finding that short-term treatment with lithium enhances fos expression in the brain suggests a mechanism for its therapeutic action. (PMID: 1718537) 0/0
Lithium enhances 5-HT2A receptor-mediated c-fos expression in rat cerebral cortex. (PMID: 8298081) 0/0
We find that lithium increases the level of fos mRNA that occurs in response to receptor and postreceptor activation of PKC. (PMID: 2119851) 0/0
Lithium INHIBITS TP53|TP53 gene Correct? #Y/N
Lithium attenuates p53 levels in human neuroblastoma SH-SY5Y cells. (PMID: 10321495) 0/0
In addition, it has been shown that Li decreases the expression of p53 , which plays a prominent role in apoptosis and regulates the expression of Bcl-2. (PMID: 22484386) 0/0
Here, we show by epistatic analysis that p53 inhibition results in a maximum level of autophagy that cannot be further enhanced by a variety of different autophagy inducers including lithium, tunicamycin-induced stress of the endoplasmic reticulum (ER) or inhibition of Bcl-2 and Bcl-X(L) with the BH3 mimetic ABT737. (PMID: 18838865) 0/0
Lithium STIMULATES CAMP|CAMP gene Correct? #Y/N
Enhancement by lithium of cAMP-induced CRE/CREB-directed gene transcription conferred by TORC on the CREB basic leucine zipper domain. (PMID: 17696880) 0/0
Recently, the CREB-co-activator TORC (transducer of regulated CREB) has been identified as a novel target of lithium and shown to confer an enhancement of cAMP-induced CREB-directed gene transcription by lithium. (PMID: 18717645) 0/0
Taken together the results exclude a competition between lithium and magnesium at the bZip, but suggest that lithium by enforcing the CRTC-oligomer formation and the interaction of CREB-CBP-CRTC enhances cAMP-induced CREB-dependent gene transcription. (PMID: 23000340) 0/0
Lithium INTERACTS_WITH PTH|PTH gene Correct? #Y/N
In a previous study we observed that during perfusion of normal human parathyroid tissue, the release of PTH (1-84) was modulated by ambient extracellular calcium (Ca++) and lithium (Li+) concentrations in the media and preliminary studies indicated that this stimulus-response coupling was absent in human parathyroid adenoma fragments. (PMID: 8844452) 0/0
The effect of lithium on PTH release from human parathyroid tissue was studied using a perifusion system and an immunoradiometric assay for intact human PTH. (PMID: 3372682) 0/0
The data on the effects of Li on baseline PTH and calcium (Ca) levels are conflicting. (PMID: 9284708) 0/0
Lithium STIMULATES ADRBK1|ADRBK1 gene Correct? #Y/N
Lithium enhances cortical mRNA expression in ovariectomized C57BL/6J mice. (PMID: 20871648) 0/0
Our results indicate that in bOVX C57BL/6J mice, lithium enhances the expression of specific cortical genes coded for proteins involved in learning, memory and neuroprotection. (PMID: 20871648) 0/0
In contrast, cortical, beta-, and gamma-ENaC were increased by lithium (~50%), but only in WT mice. (PMID: 23739592) 0/0
Lithium INTERACTS_WITH Genes, Immediate-Early Correct? #Y/N
This suggests that chronic lithium selectively alters immediate-early gene expression in brain. (PMID: 8298081) 0/0
Neither chronic lithium nor VPA affected Homer immediate-early genes . (PMID: 22245542) 0/0
Lithium INTERACTS_WITH TRH|TRH gene Correct? #Y/N
Acute, chronic and withdrawal effect of lithium on TRH and TRH-like peptide levels in young, adult male Sprague-Dawley rats: Rats were divided into four lithium treatment groups. (PMID: 12401339) 0/0
Acute, chronic and withdrawal effect of lithium on TRH and TRH-like peptide levels in young, adult male Sprague-Dawley rats: Rats were divided into four lithium treatment groups. (PMID: 12401339) 0/0
Lithium INTERACTS_WITH GPI|GPI gene Correct? #Y/N
To this aim, we tested several antipsychotics, antidepressants, anticonvulsants, and lithium for effects on neuronal pHi , using guinea pig hippocampal slice preparations in which CA 3 pyramidal neurons were loaded with the pHi-sensitive dye BCECF-AM. (PMID: 21598206) 0/0
To examine a possible effect of lithium on pHi and the relationship between pHi and WMHI, seven drug-free euthymic bipolar patients were examined, and T2-weighted MRI were examined in 14 previously reported bipolar patients. (PMID: 9928909) 0/0
Lithium INTERACTS_WITH GRIA3|GRIA3 gene Correct? #Y/N
By using cyclothiazide (CTZ) to reduce desensitization of GluR3, we find that for low concentrations of KA and glutamate potentiation of the response by a combination of CTZ and Li+ is no greater than by CTZ or Li+ alone. (PMID: 10200187) 0/0
By using cyclothiazide (CTZ) to reduce desensitization of GluR3, we find that for low concentrations of KA and glutamate potentiation of the response by a combination of CTZ and Li+ is no greater than by CTZ or Li+ alone. (PMID: 10200187) 0/0
Lithium STIMULATES TP53|TP53 gene Correct? #Y/N
Selective G2/M arrest in a p53(Val135)-transformed cell line induced by lithium is mediated through an intricate network of MAPK and beta-catenin signaling pathways. (PMID: 22884810) 0/0
Since increased nuclear p53 is a critical intermediate step in many signaling processes that culminate in cell death, attenuation of p53 activation by lithium reveals a mechanism by which lithium may support neuronal survival. (PMID: 10321495) 0/0
Lithium INTERACTS_WITH JUN|JUN gene Correct? #Y/N
Previous studies in our laboratory have shown that the mood stabilizers, lithium and valproate (VPA), regulate the transcription factors, cyclic AMP responsive element binding protein (CREB), c-Fos and c-Jun , differentially in cultured human neuroblastoma SH-SY5Y cells. (PMID: 10381542) 0/0
Partial involvement of c-jun protooncogene in growth enhancing and cytotoxic effects of lithium in vitro. (PMID: 14682396) 0/0
Lithium Chloride STIMULATES FOS|FOS gene Correct? #Y/N
Compared with saline treatment, LiCl increased Fos only slightly in the area postrema, nucleus of the solitary tract, and lateral parabrachial nucleus on P0. (PMID: 17082349) 0/0
Taste-malaise association induced specific Fos activation in the insular cortex (with both the low and the high doses of LiCl) and the nucleus accumbens shell (with the high LiCl dose only). (PMID: 16893300) 0/0
Lithium INTERACTS_WITH APP|APP gene Correct? #Y/N
Further, GSK3 inhibitor lithium blocked Pin1 binding to C99 by decreasing Thr668 phosphorylation and attenuated Abeta generation, explaining the inhibitory effect of lithium on Abeta generation. (PMID: 16139797) 0/0
Abeta(1-42)-induced JNK and ERK activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau. (PMID: 14625087) 0/0
Lithium INHIBITS Genes Correct? #Y/N
Although lithium reduces the expression of genes common to both white and brown adipocytes [fatty acid binding protein aP2 (aP2/FABP) or peroxisome proliferating activated receptor gamma], genes expressed differentially in brown adipocytes, i.e., uncoupling protein 1, PPAR gamma coactivator-1alpha, and peroxisome proliferating activated receptor alpha, are particularly sensitive to lithium treatment-dependent downregulation. (PMID: 15757659) 0/0
In addition, some genes were oppositely regulated, i.e., downregulated by lithium, upregulated by MPTP, and maintained in mice fed with LiCl supplemented diet and treated with MPTP, among these genes were basic fibroblast growth factor receptor 1 precursor, inhibin alpha subunit, glutamate receptor subunit zeta 1 precursor (NMD-R1), postsynaptic density protein-95 which together with NMD-R1 can form an apoptotic promoting complex. (PMID: 23324999) 0/0
Lithium INTERACTS_WITH Neuropeptide Gene Correct? #Y/N
This result demonstrates that lithium can profoundly influence the expression of a specific neuropeptide gene in a previously unanticipated manner and suggests that changes in gene expression might be involved in its therapeutic activity. (PMID: 2844750) 0/0
In this report, we have analyzed the effect of lithium on two neuropeptide encoding genes that are regulated by second messenger systems; (PMID: 1372067) 0/0
Lithium STIMULATES PTH|PTH gene Correct? #Y/N
Less known is the increase of PTH and calcium levels induced by lithium. (PMID: 24572579) 0/0
Addition of lithium in concentrations equivalent to the therapeutic serum levels normally attained in man (1.3 mmol/L) resulted in a significant (P less than 0.05) increase in PTH release under normocalcemic (1.15 mmol/L) conditions from normal and hyperplastic tissues. (PMID: 3372682) 0/0
Lithium Chloride INHIBITS GRIN1|NDOR1|NR1 gene Correct? #Y/N
Subsequent analysis of cortical cell cultures indicated that combined E2/LiCl decreased NR1 mRNA expression after a 12 and 48 h treatment period. (PMID: 19285052) 0/0
Our results showed combined E2/LiCl reduced NR1 mRNA and prevented protection against glutamate excitotoxicity in glial primary cultures. (PMID: 19285052) 0/0
Lithium INTERACTS_WITH CAMP|CAMP gene Correct? #Y/N
We here for the first time show that lithium regulates CRE/CREB-directed gene transcription in vivo and suggest CREB as a putative mediator of the neuronal adaptation after chronic lithium treatment. (PMID: 18046304) 0/0
We here investigated the effect of lithium on cAMP-responsive element (CRE)/CREB-mediated gene transcription in the brain, using transgenic reporter mice that express the luciferase reporter gene under the control of four copies of the rat somatostatin gene promoter CRE. (PMID: 18046304) 0/0
Lithium STIMULATES RET|RET gene Correct? #Y/N
Lithium induces c-Ret expression in mouse inner medullary collecting duct cells. (PMID: 20940044) 0/0
This region contained three putative GC-rich Sp1 binding sites found to be essential for c-Ret induction by Li(+). (PMID: 20940044) 0/0
Lithium NEG_INTERACTS_WITH Neomycin resistance gene Correct? #Y/N
The stability of neo mRNA was not altered by lithium, since in cells infected with retrovirus containing only the neo gene transcribed via the retroviral 5'-LTR and treated with 20 mM LiCl, no change in neo mRNA levels was observed. (PMID: 1371108) 0/0
Lithium Chloride STIMULATES IL2|IL2 gene Correct? #Y/N
However, LiCl potentiated the IL-1-induced synthesis of IL-6, GM-CSF, IL-3, and IL-2 in PC60 murine T-cell hybridoma cells. (PMID: 1651781) 0/0
Lithium Chloride STIMULATES IL3|IL3 gene Correct? #Y/N
However, LiCl potentiated the IL-1-induced synthesis of IL-6, GM-CSF, IL-3 , and IL-2 in PC60 murine T-cell hybridoma cells. (PMID: 1651781) 0/0
Lithium Chloride STIMULATES IL1B|IL1B gene Correct? #Y/N
The effects of LiCl on the TNF-induced and the IL-1-induced gene expression seem to be independent of the protein kinase A and C pathways. (PMID: 1651781) 0/0
Lithium STIMULATES PPP3CA|PPP3CA gene Correct? #Y/N
KW-3902 increased urine volume (UV), sodium excretion and renal clearances of sodium (CNa) and lithium (CLi), when UV and CNa increased more than CLi. (PMID: 8483302) 0/0
Lithium NEG_INTERACTS_WITH TNFRSF10B|TNFRSF10B gene Correct? #Y/N
In vitro exposure of effector-target mixture to graded concentrations of lithium did not substantially modify the natural killer activity of mouse splenocytes, untreated or pretreated with cyclophosphamide. (PMID: 3361072) 0/0
Lithium INTERACTS_WITH PLAT|PLAT gene Correct? #Y/N
Two sublines of a human promyelocytic cell line, HL-60, were used to study the effect of lithium on TPA (12-o-tetradecanoylphorbol-13-acetate) induced macrophage-like differentiation. (PMID: 1895753) 0/0
Lithium INHIBITS FOS|FOS gene Correct? #Y/N
Chronic dietary lithium inhibits basal c-fos mRNA expression in rat brain. (PMID: 8787041) 0/0
Lithium Chloride COEXISTS_WITH FOS|FOS gene Correct? #Y/N
Rats treated with a single intraperitoneal injection of lithium chloride exhibited a substantial increase in pilocarpine-mediated fos expression. (PMID: 1718537) 0/0
Lithium NEG_STIMULATES FOS|FOS gene Correct? #Y/N
In contrast, fos expression induced in several brain regions by a single electroconvulsive shock is not augmented by lithium. (PMID: 1718537) 0/0
Lithium INHIBITS HGS|HGS gene Correct? #Y/N
Myo-inositol (i.c.v.) reversed the suppression of rearing behavior 24 hrs after an acute dose of lithium (5 mEq/kg) but did not attenuate hypokinesia 24 hrs after a high dose of lithium (10 mEq/kg). (PMID: 1775587) 0/0
Lithium INHIBITS PTH|PTH gene Correct? #Y/N
Ryanodine (1 microM), caffeine (10 mM), lithium (2 mM), or cyclopiazonic acid (2-5 microM), agents that interfere with intracellular Ca2+ release, all failed to block PTH (52-84) induced [Ca2+]i increases. (PMID: 9924633) 0/0
Lithium INTERACTS_WITH MAP Kinase Gene Correct? #Y/N
Since both NF-kappa B and MAP kinases are also important mediators of inflammatory gene expression, we investigated the effect of lithium on NF-kappa B- and MAP kinase-mediated inflammatory gene expression. (PMID: 11756416) 0/0
Lithium Chloride NEG_INTERACTS_WITH TFAP2A|TFAP2A gene Correct? #Y/N
In contrast, chronic administration of lithium-chloride (40 mg/kg) did not affect the amount of the two AP-2 isoforms. (PMID: 11205881) 0/0
Lithium INTERACTS_WITH HGS|HGS gene Correct? #Y/N
Renal elimination of K decreases under the influence of lithium 48 hrs. after administering one dose of lithium. (PMID: 11068611) 0/0
Lithium compared_with IL8|IL8 gene Correct? #Y/N
In the present study, taurine, lithium and Quillaja saponin (Q-SAP) were compared with NaF with respect to their enhancement of serum IgG antibody response in chickens after oral immunization. (PMID: 10099029) 0/0
Lithium NEG_INTERACTS_WITH GRIN1|NDOR1|NR1 gene Correct? #Y/N
Lithium pre-treatment did not alter total protein levels of NR1 , NR2A and NR2B subunits of NMDA receptors. (PMID: 11841566) 0/0
Lithium INTERACTS_WITH IL2|IL2 gene Correct? #Y/N
[Modulation effect of lithium on IL-2 and IFNr production by human peripheral blood mononuclear cells]. (PMID: 1337888) 0/0
Lithium STIMULATES IL2|IL2 gene Correct? #Y/N
The IL-2 and IFNr levels were significantly increased by both lithium and rIL-2 but the effect of lithium was more potent. (PMID: 1337888) 0/0
Lithium COEXISTS_WITH PML gene Correct? #Y/N
Lithium and hydrocortisone interactions on cell growth and gene expression in human promyelocytic leukemia (HL60). (PMID: 2523989) 0/0
Lithium STIMULATES Genes, Reporter Correct? #Y/N
Additionally, in both SY5Y and C6 cells transiently transfected with a reporter gene vector driven by an SV40 promoter, lithium increased the activity of the reporter gene in a time- and concentration-dependent manner. (PMID: 9685653) 0/0
Lithium COEXISTS_WITH HTR2A|HTR2A gene Correct? #Y/N
5-HT2A and 2C variants are not, therefore, associated with lithium prophylactic efficacy in mood disorders. (PMID: 10758249) 0/0
Lithium Chloride INHIBITS MAPK3|MAPK3 gene Correct? #Y/N
Tau phosphorylation and rephosphorylation after stress was mediated by glycogen synthase kinase 3beta (GSK-3beta), and not by ERK1,2 and could be suppressed by lithium chloride, a specific inhibitor of GSK-3beta. (PMID: 12420308) 0/0
Lithium INTERACTS_WITH HTR2A|HTR2A gene Correct? #Y/N
Our study was designed to investigate the effect of lithium on the 5-HT2A or 5-HT2C (5-HT2A/2C) receptor subtypes, by comparing the consequences of chronic pre-treatment of rats with lithium on 5-HT2A/2C receptor-mediated behavioural responses, Fos expression, and the density of these receptors in the brain. (PMID: 9681934) 0/0
Lithium INTERACTS_WITH Thyroid Hormone Receptor Gene Correct? #Y/N
It remains to be determined whether the observed effects of lithium on THR gene expression are related to its therapeutic efficacy in the treatment of bipolar disorder. (PMID: 10350353) 0/0
Lithium Chloride STIMULATES ADRBK1|ADRBK1 gene Correct? #Y/N
2) the cortical expression of ICER mRNA by LiCl occurs in a dose-dependent manner; (PMID: 16175568) 0/0
Lithium INHIBITS FAS|TNFRSF6 gene Correct? #Y/N
GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression. (PMID: 15475000) 0/0
Lithium Chloride INTERACTS_WITH TSC2|TSC2 gene Correct? #Y/N
Inhibition of GSK3 by lithium chloride reduced its association with TSC1 whereas disruption of GSK3-phosphorylation sites in TSC1 reduced interaction between TSC2 and TSC1. (PMID: 15972957) 0/0
Lithium Chloride NEG_STIMULATES FOS|FOS gene Correct? #Y/N
LiCl did not increase Fos above control levels in the central nucleus of the amygdala, bed nucleus of the stria terminalis (BNST), or paraventricular nucleus of the hypothalamus on P0 but did on P7 and later. (PMID: 17082349) 0/0
Lithium Chloride NEG_INTERACTS_WITH SMAD3|SMAD3 gene Correct? #Y/N
Lithium chloride did not influence degradation of Smad3 but resulted in decreased nuclear translocation. (PMID: 17623674) 0/0
Lithium INTERACTS_WITH MAPK1|MAPK1 gene Correct? #Y/N
Interestingly, pERK2 levels are also controlled by another bipolar disorder drug, lithium, providing a common effect of these two drugs. (PMID: 16759735) 0/0
Lithium INTERACTS_WITH ATM|ATM gene Correct? #Y/N
The effects of the specific angiotensin II receptor type I (AT1) antagonist candesartan on renal proximal tubular sodium transport were studied using lithium clearance. (PMID: 16173927) 0/0
Lithium INHIBITS Orthologous Gene Correct? #Y/N
As opposed to the rat and flounder orthologs, hNaDC-3 was hardly inhibited by lithium concentrations up to 5 mM. (PMID: 15561973) 0/0
Lithium Chloride STIMULATES APP|APP gene Correct? #Y/N
In both cellular models, a nontoxic concentration of LiCl increased the production of Abeta by increasing the beta-cleavage of amyloid precursor protein, generating more substrate for an unmodified gamma-secretase activity. (PMID: 16014628) 0/0
Lithium COEXISTS_WITH BCR|BCR gene Correct? #Y/N
In this study, we examined a possible relationship between response to maintenance treatment of lithium and Asn796Ser single-nucleotide polymorphism in the BCR gene. (PMID: 17822820) 0/0
Lithium INTERACTS_WITH GSTA4|GSTA4 gene Correct? #Y/N
The present findings suggest that regulation of GST M1, and possibly GST A4, may mediate the anti-oxidative effects of valproate treatment, and regulation of GST may be involved in the mood stabilizing effect of valproate and lithium. (PMID: 15009649) 0/0
Lithium COEXISTS_WITH CYP3A5|CYP3A5 gene Correct? #Y/N
We analyzed the association of variants of the ABCB1 and CYP3A5 genes with ambulatory blood pressure, plasma renin activity, plasma aldosterone, endogenous lithium clearance, and blood pressure response to treatment in 72 families (373 individuals; (PMID: 17372036) 0/0
Lithium COEXISTS_WITH TNFRSF10B|TNFRSF10B gene Correct? #Y/N
Lithium also did not produce an increase in NK activity and ADCC. (PMID: 2898486) 0/0
Lithium INTERACTS_WITH Calcitonin Gene-Related Peptide Correct? #Y/N
Effect of lithium on tachykinins, calcitonin gene-related peptide, and neuropeptide Y in rat brain. (PMID: 2366266) 0/0
Lithium salt INTERACTS_WITH ADRBK1|ADRBK1 gene Correct? #Y/N
The present behavioral observations would tend to support the hypothesis that lithium salts modify the circadian structure of emotionality by cortical modulation rather than only by physiological subcortical integrations. (PMID: 2805942) 0/0
Lithium COEXISTS_WITH ADRBK1|ADRBK1 gene Correct? #Y/N
The effect of ouabain and lithium on acidification in cortical and medullary collecting tubules derived from starved New Zealand white rabbits was studied by using the techniques of isolated nephron microperfusion and microcalorimetric determination of total CO2 flux. (PMID: 6417167) 0/0
lithium hydroxybutyrate INHIBITS TNFRSF10B|TNFRSF10B gene Correct? #Y/N
The possible use of sodium hydroxybutyrate and lithium hydroxybutyrate for the prevention of the decrease in splenic natural killer activity has been studied in CBA mice upon 6-hour immobilization stress. (PMID: 3779089) 0/0
Lithium Chloride COEXISTS_WITH STAT3|STAT3 gene Correct? #Y/N
Administration of GSK-3beta inhibitors lithium chloride and L803-mts restored glucose homeostasis and rescued the glucose intolerance and impaired insulin response in L-Stat3 (-/-) mice. (PMID: 18268048) 0/0
Lithium Chloride STIMULATES FOSL1|FOSL1 gene Correct? #Y/N
Treatment of these cells with LiCl also increased the mRNA levels of ALP, FosB, and Fra1 in a dose-dependent manner. (PMID: 20848229) 0/0
Lithium Chloride STIMULATES FOSB|FOSB gene Correct? #Y/N
Treatment of these cells with LiCl also increased the mRNA levels of ALP, FosB , and Fra1 in a dose-dependent manner. (PMID: 20848229) 0/0
Lithium INHIBITS STAT3|STAT3 gene Correct? #Y/N
Lithium strongly inhibited STAT3 (signal transducer and activator of transcription 3) activation, a messenger system known to promote astrogliogenesis and cancer. (PMID: 21931595) 0/0
Lithium Chloride INTERACTS_WITH GRIN1|NDOR1|NR1 gene Correct? #Y/N
Estradiol and lithium chloride specifically alter NMDA receptor subunit NR1 mRNA and excitotoxicity in primary cultures. (PMID: 19285052) 0/0
Lithium STIMULATES SMAD3|SMAD3 gene Correct? #Y/N
Also observed was the interaction between GSK-3beta and Smad3, which was enhanced by lithium. (PMID: 21310903) 0/0
Lithium INHIBITS CAMP|CAMP gene Correct? #Y/N
Treatment of stressed mice with lithium decreased stress-induced CRE/CREB-directed gene expression to control levels in nearly all brain regions and likewise reduced CREB phosphorylation. (PMID: 18046304) 0/0
Lithium INTERACTS_WITH BCL2|BCL2 gene Correct? #Y/N
It is likely that the regulation of Bcl-2 gene expression by lithium and by deafferentation involves different molecular pathways. (PMID: 18313644) 0/0
Lithium STIMULATES SNX3|SNX3 gene Correct? #Y/N
Here, we show that lithium upregulates the expression of sorting nexin 3 (SNX3), one of the Phox (PX) domain-containing proteins involved in endosomal sorting, and regulates neurite outgrowth in mouse N1E-115 neuroblastoma cells. (PMID: 19576982) 0/0
Lithium INTERACTS_WITH TP53|TP53 gene Correct? #Y/N
The phosphorylation level of p53 decreased upon tau overexpression, and a more profound reduction of the phosphorylated p53 was detected when the cells were treated with lithium and roscovitine, inhibitors of GSK-3 and cyclin-dependent kinase-5 (Cdk-5). (PMID: 20413892) 0/0
Lithium INTERACTS_WITH SP1|SP1 gene Correct? #Y/N
Moreover, we found in rat cerebellar granule neurons that under non-depolarizing conditions SP4, but not SP1, was polyubiquitinated and degraded by the proteasome while lithium stabilized SP4 protein. (PMID: 22017217) 0/0
Lithium INTERACTS_WITH USF2|USF2 gene Correct? #Y/N
In addition, the genes for USF1 and USF2 are differentially regulated by lithium in these cells. (PMID: 20690045) 0/0
Lithium INTERACTS_WITH USF1|USF1 gene Correct? #Y/N
In addition, the genes for USF1 and USF2 are differentially regulated by lithium in these cells. (PMID: 20690045) 0/0
Lithium STIMULATES Genes Correct? #Y/N
This gene was the only SLC6 gene induced by lithium, and was thus designated as Lithium-inducible SLC6 transporter or List. (PMID: 19619614) 0/0
Lithium INTERACTS_WITH TCF7L2|TCF7L2 gene Correct? #Y/N
The balance of TCF7L2 variants with differential activities in Wnt-signaling is regulated by lithium in a GSK3beta-independent manner. (PMID: 20654575) 0/0
Lithium STIMULATES TCF7L2|TCF7L2 gene Correct? #Y/N
Lithium , a Wnt-signaling activator, increases TCF7L2 mRNA levels and induces an RNA isoform switch favoring the expression of TCF7L2-short forms lacking the C-termini domains. (PMID: 20654575) 0/0
Lithium COEXISTS_WITH PKM|PKM2 gene Correct? #Y/N
Lithium inhibition was demonstrated at pharmacologically significant lithium concentrations (7%-12% at 2 mmol 1-1 Li) and this was similar in character to that previously seen in rabbit muscle pyruvate kinase , namely noncompetitive with respect to phosphoenol pyruvate, K+, and Mg2+ but competitive with ADP. (PMID: 541684) 0/0
Lithium compared_with RPS19|RPS19 gene Correct? #Y/N
The susceptibility of the inbred strains of mice to the activity-suppressant effect of lithium was C3H greater than DBA greater than BALB = C57. (PMID: 1005485) 0/0
Lithium higher_than RPS19|RPS19 gene Correct? #Y/N
The susceptibility of the inbred strains of mice to the activity-suppressant effect of lithium was C3H greater than DBA greater than BALB = C57. (PMID: 1005485) 0/0
Lithium INHIBITS PKM|PKM2 gene Correct? #Y/N
Inhibition of rabbit muscle pyruvate kinase by lithium [proceedings]. (PMID: 912173) 0/0
Lithium COEXISTS_WITH NEDD4|NEDD4 gene Correct? #Y/N
Variations in the NEDD4L gene are associated with SLC activity. (PMID: 21088674) 0/0
Lithium STIMULATES EGR1|EGR1 gene Correct? #Y/N
Lithium also upregulated the expression of Per2 and Egr1 in mouse frontal cortex. (PMID: 23816566) 0/0
Lithium salt STIMULATES CAMP|CAMP gene Correct? #Y/N
Molecular mechanisms of lithium salts in enhancement of cAMP-stimulated CREB-dependent gene transcription. (PMID: 23327573) 0/0
Lithium NEG_INTERACTS_WITH GPI|GPI gene Correct? #Y/N
In contrast, venlafaxine, the anticonvulsants carbamazepine, clonazepam, gabapentin, lamotrigine, zonisamide, and the mood stabilizer lithium had no effect on neuronal pHi . (PMID: 20015293) 0/0
Lithium Chloride STIMULATES Genes Correct? #Y/N
Knocking-down the Wnt/beta-catenin components by siRNAs inhibited both TTF-1 transcript and protein expression, while mimicking the activation of Wnt signaling by lithium chloride induced TTF-1 gene and protein expression. (PMID: 21814573) 0/0
Lithium INTERACTS_WITH Structural gene Correct? #Y/N
These results suggest that lithium and VPA similarly modulate the expression of structural postsynaptic genes with topographic specificity in cortical and subcortical regions. (PMID: 22245542) 0/0
Lithium NEG_INHIBITS ADRBK1|ADRBK1 gene Correct? #Y/N
In contrast, medullary levels of Na+-K+-2Cl- cotransporter 2 and cortical levels of the renal outer medullary K+ channel were not downregulated by lithium and were significantly (15-76%) higher in KO mice under both dietary conditions. (PMID: 23739592) 0/0
Lithium Chloride STIMULATES TP53|TP53 gene Correct? #Y/N
Moreover, in the presence of lithium chloride there were increased levels of p53 in cytoplasm and nucleus (p<0.05). (PMID: 23408470) 0/0
Lithium INTERACTS_WITH KL|KL gene Correct? #Y/N
The present study explored whether lithium influences renal Klotho expression, FGF23 serum levels, 1,25(OH)2D3 formation, and renal phosphate excretion. (PMID: 24013758) 0/0
Lithium Chloride STIMULATES TLR4|TLR4 gene Correct? #Y/N
The effect of Lithium Chloride (LiCl) was compared on the response of TLR4 agonist , LPS and TLR2 agonist, PAM3CSK4 stimulated aged and young DCs. (PMID: 23988651) 0/0
Lithium STIMULATES GPI|GPI gene Correct? #Y/N
The third 'classical' anti-bipolar drug, 'lithium ' increases astrocytic pHi by a different mechanism (stimulation of the acid extruding Na(+)/H(+) exchanger NHE1). (PMID: 24037520) 0/0
Lithium INHIBITS JUN|jun Genes Correct? #Y/N
On the other side, a survival pathway initiated by lithium leads to repression of pro-apoptotic c-Jun/AP-1 target genes without interfering with JNK activity. (PMID: 24113186) 0/0
Lithium INHIBITS JUN|JUN gene Correct? #Y/N
Yet, the mechanism by which lithium inhibits c-Jun activity remains to be elucidated. (PMID: 24113186) 0/0
Lithium INTERACTS_WITH FYN|FYN gene Correct? #Y/N
[1,5]-Anion relay via intramolecular proton transfer to generate 3,3-bis(silyl) allyloxy lithium : a useful scaffold for syn -addition to aldehydes and ketones. (PMID: 24499418) 0/0
Genes ASSOCIATED_WITH Brugada syndrome Correct? #Y/N
A missense mutation (L10P) was detected in exon 1 of SCN3B, the beta 3 subunit of the cardiac sodium channel, but not in any other gene known to be associated with Brugada syndrome or in 296 controls. (PMID: 20031595) 0/0
A R214Q variant was detected in exon 3A of SCN1Bb (Na(v)1B) in all three probands, but not in any other gene previously associated with BrS or SIDS. (PMID: 22155597) 0/0
EXEGESIS: This article briefly describes the clinical features and the genes associated with the congenital long QT syndrome, the short QT syndrome, Brugada's syndrome , catecholaminergic polymorphic ventricular tachycardias and arrhythmogenic right ventricular dysplasia. (PMID: 16406208) 0/0
To date, more than 250 different mutations in seven genes have been identified as causing LQTS, whereas the only gene identified to be linked to BrS is SCN5A. (PMID: 16105490) 0/0
No mutations were identified in genes previously associated with BrS or AF in these patients. (PMID: 22155598) 0/0
Data regarding genotype-phenotype relationships are limited, since SCN5A, the gene encoding the a subunit of the sodium channel, is as yet the only gene linked to Brugada syndrome . (PMID: 16119703) 0/0
More than 300 variants in 12 genes have been associated with Brugada syndrome (BrS) which has a prevalence ranging between 1:2000 and 1:100,000. (PMID: 23414114) 0/0
Today, hundreds of variants in 17 genes have been associated with BrS of which mutations in SCN5A, coding for the cardiac voltage-gated sodium channel, accounts for the vast majority. (PMID: 23874304) 0/0
Several studies have shown an overlap between genes involved in the pathophysiological mechanisms of atrial fibrillation (AF) and Brugada Syndrome (BrS). (PMID: 24667784) 0/0
SCN5A, the gene encoding the alpha subunit of the sodium channel, is the only gene thus far linked to the Brugada syndrome but is identified in only 18% to 30% of patients with clinically diagnosed Brugada syndrome. (PMID: 16226070) 0/0
SCN5A, the gene encoding the alpha subunit of the sodium channel, is the only gene thus far linked to Brugada syndrome ; (PMID: 16415541) 0/0
The only gene thus far linked to the Brugada syndrome is the cardiac sodium channel gene, SCN5A. (PMID: 10358800) 0/0
SCN5A|SCN5A gene ASSOCIATED_WITH Brugada syndrome Correct? #Y/N
The mutations of the SCN5A gene have been implicated to play a pathogenetic role in Brugada syndrome , which causes ventricular fibrillation. (PMID: 12639704) 0/0
A novel mutation in the SCN5A gene is associated with Brugada syndrome . (PMID: 17141278) 0/0
A novel missense mutation in the SCN5A gene associated with Brugada syndrome bidirectionally affecting blocking actions of antiarrhythmic drugs. (PMID: 15877619) 0/0
Heterozygous mutations in the SCN5A gene have been found to be associated with long QT syndrome, Brugada syndrome , and sinus node dysfunction (SND). (PMID: 20564468) 0/0
BACKGROUND: Mutations in the SCN5A gene have been linked to Brugada syndrome (BrS), conduction disease, Long QT syndrome (LQT3), atrial fibrillation (AF), and to pre- and neonatal ventricular arrhythmias. (PMID: 21895525) 0/0
The SCN5A gene in Brugada syndrome : mutations, variants, missense and nonsense. (PMID: 20129285) 0/0
Mutations in the SCN5A gene encoding the cardiac voltage-gated Na+ channel (hNav1.5) are associated with Brugada syndrome . (PMID: 15057319) 0/0
The region of linkage contains potassium and sodium channel genes, including the SCN5A gene , which has been implicated in one form of the long QT syndrome and in the Brugada syndrome . (PMID: 15851319) 0/0
RESULTS: We identified a novel mutation N1774S in the SCN5A gene of the BS family, a novel mutation G314S in a RWS family which had also been found in Europe, North America, and Japan, and a single nucleotide polymorphisms (SNPs) G643S in the KCNQ1 of the JLNS family. (PMID: 16038262) 0/0
SCN5A|SCN5A gene CAUSES Brugada syndrome Correct? #Y/N
Mutations in the SCN5A gene can lead to the Brugada syndrome , a genetically inherited form of idiopathic ventricular fibrillation that has a characteristic ECG phenotype usually restricted to precordial leads V1-V3. (PMID: 12693506) 0/0
CONCLUSIONS: We conclude that the same mutation in the SCN5A gene can lead either to Brugada syndrome or to an isolated cardiac conduction defect. (PMID: 11748104) 0/0
A novel nonsense mutation in the SCN5A gene leads to Brugada syndrome and a silent gene mutation carrier state. (PMID: 16239976) 0/0
Mutations in the SCN5A gene can cause Brugada syndrome , a genetically inherited form of idiopathic ventricular fibrillation. (PMID: 16426410) 0/0
In this study we characterized a new mutation in the SCN5A gene (T1620M), causing the Brugada syndrome . (PMID: 10664447) 0/0
CONCLUSIONS: Mutation in SCN5A gene is one of the causes of Brugada syndrome in Chinese. (PMID: 17081365) 0/0
BACKGROUND: Mutations in the SCN5A gene , which encodes the cardiac sodium channel, have been implicated in the pathogenesis of Brugada syndrome (BrS). (PMID: 19648062) 0/0
Genes CAUSES Brugada syndrome Correct? #Y/N
We screened patients with SUNDS for mutations in SCN5A, the gene known to cause Brugada syndrome , as well as genes encoding ion channels associated with the long-QT syndrome. (PMID: 11823453) 0/0
Genes responsible for the long QT syndrome, Brugada syndrome , and polymorphic ventricular tachycardia have been identified. (PMID: 12015471) 0/0
A comprehensive genetic analysis of all genes to date responsible for Brugada syndrome was performed in the index case. (PMID: 24142675) 0/0
Mutations in eight genes (SCN5A, GPD1L, CACNA1C, CACNB2, SCN1B, KCNE3, SCN3B, and HCN4) are known to cause Brugada syndrome . (PMID: 20301690) 0/0
Over the past 10 years, remarkable advances have been made in identifying the genes responsible for primary electrical heart diseases, such as congenital long QT syndrome and Brugada syndrome . (PMID: 17587741) 0/0