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Subject cui: C0812250|1112 Name: FOXN3|CHES1 gene Sem. type: gngm|gngm Novel: true


Object cui: C1332120|545 Name: ATR|ATR gene Sem. type: gngm|gngm Novel: true

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FOXN3|CHES1 gene STIMULATES ATR|ATR gene Correct? #Y/N
The activation of ATM, ATR, Chk1, and Chk2; (PMID: 22178412) 0/0
Main features of the checkpoints include activation of ATM and ATR by sensors of DNA damage, which activates effector kinases CHK1 and CHK2; (PMID: 24503238) 0/0
The cellular DNA damage response (DDR) entails the activation of ATM, ATR and/or DNA PK protein kinases that causes modifications of proteins including Chk1, Chk2 and 53BP1, aggregation of DDR proteins into foci, and activation of p53. (PMID: 18440596) 0/0
Consistent with ATM or ATR activation, hyperoxia induced wortmannin-sensitive phosphorylation of Chk1, Chk2, and p53. (PMID: 15533933) 0/0
Primary macrophages are refractory to ATR activation by Vpr, a finding that is consistent with the lack of detectable ATR, Rad17, and Chk1 protein expression in these nondividing cells. (PMID: 16956949) 0/0
Consistent with its role in ATR activation, HCLK2 depletion severely impaired phosphorylation of multiple ATR targets including Chk1, Nbs1, and Smc1 after DNA damage. (PMID: 19097996) 0/0