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Subject cui: C0079419|7157 Name: TP53|TP53 gene Sem. type: gngm|gngm Novel: true

Predicate: STIMULATES

Object cui: C1332120|545 Name: ATR|ATR gene Sem. type: gngm|gngm Novel: true

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TP53|TP53 gene STIMULATES ATR|ATR gene Correct? #Y/N
By using ATM- and ATR-defective cells, phosphorylation on Chk1, Chk2, and p53 was found to be ATM-dependent , whereas ATR also contributed to Chk1 phosphorylation. (PMID: 15533933) 0/0
We suggest the anti-proliferative actions of THIF may be mediated by initial oxidative DNA damage, activation of ATR and downstream regulation of the p53 and Chk1 pathways leading to cell cycle arrest in G2-M. (PMID: 17976513) 0/0
Previous studies demonstrate that nitric oxide (NO) promotes p53 transcriptional activity by a classical DNA damage responsive mechanism involving activation of ATM/ATR and phosphorylation of p53. (PMID: 20499882) 0/0
Consistent with ATM or ATR activation, hyperoxia induced wortmannin-sensitive phosphorylation of Chk1, Chk2, and p53. (PMID: 15533933) 0/0
Cells that survived exposure to Ras continued to exhibit replication stress (ATR activation) but no longer exhibited gammaH2A.X or full activation of p53. (PMID: 17079472) 0/0
Moreover, we show the reduced ATR levels in HPV 5 and 8 E6 expressing cells results in delayed ATR activation and an attenuated ability of cells to phosphorylate, and as a result accumulate, p53 in response to UVB exposure, leading to significantly reduced cell cycle arrest. (PMID: 22807682) 0/0