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Subject cui: C0282552 Name: beta-Chemokines Sem. type: aapp Novel: true

Predicate: STIMULATES

Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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beta-Chemokines STIMULATES CDC42|CDC42 gene Correct? #Y/N
These data identify CC chemokines as physiological agonists of cdc42 and reveal its functional importance in chemotaxis and extravasation of monocytes. (PMID: 9692894) 0/0
Expression of cdc42 mutants in monocytic cells showed that CC chemokines regulate the rearrangement of the actin cytoskeleton via cdc42, i.e. formation of filopodia-like projections was induced by CC chemokines or dominant active cdc42, while dominant inactive cdc42 prevented its stimulation with CC chemokines. (PMID: 9692894) 0/0
Expression of cdc42 mutants in monocytic cells showed that CC chemokines regulate the rearrangement of the actin cytoskeleton via cdc42, i.e. formation of filopodia-like projections was induced by CC chemokines or dominant active cdc42, while dominant inactive cdc42 prevented its stimulation with CC chemokines. (PMID: 9692894) 0/0