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Subject cui: C0164786|207 Name: AKT1|Proto-Oncogene Proteins c-akt Sem. type: gngm|aapp Novel: true

Predicate: STIMULATES

Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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AKT1|Proto-Oncogene Proteins c-akt STIMULATES CDC42|CDC42 gene Correct? #Y/N
SigD activates Akt in epithelial cells and indirectly activates Cdc42 through one of its products, inositol 1,4,5,6-tetrakisphosphate. (PMID: 12102689) 0/0
We have confirmed a previous report that Akt is activated by expression of Rac and Cdc42 and also observed colocalization of endogenous phosphorylated Akt with Rac and Cdc42 at the leading edge of fibroblasts. (PMID: 11747822) 0/0
These results suggest that the NGF-induced ruffling requires activation of Rac1 and Cdc42, but does not require Ras, PI-3k, Akt and GSK-3beta. (PMID: 17561310) 0/0