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Subject cui: C0001461 Name: Adenosine Diphosphate Ribose Sem. type: bacs Novel: true

Predicate: STIMULATES

Object cui: C0055966|7226 Name: TRPM2|Clusterin Sem. type: gngm|aapp Novel: true

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Adenosine Diphosphate Ribose STIMULATES TRPM2|Clusterin Correct? #Y/N
Cardiac TRPM2 channels were activated by intracellular adenosine diphosphate-ribose and blocked by flufenamic acid. (PMID: 24492610) 0/0
Addition of ADP ribose , an endogenous activator of TRPM2 , to PC12 cells significantly repressed the axonal growth. (PMID: 24413888) 0/0
We report here that, in HeLa cells, intracellular adenosine diphosphate ribose (ADPr) and cyclic ADPr (cADPr), as supposed activators of TRPM2 , elicited cation currents that were virtually identical to the osmotic activation of HICCs. (PMID: 22219339) 0/0
A possible role of ADPRibase-Mn in immune cell signalling is suggested by the second-messenger role of ADP-ribose , which activates TRPM2 (transient receptor potential melastatin channel-2) ion channels as a mediator of oxidative/nitrosative stress, and by the signalling function assigned to many of the microarray profile neighbours of 2310004I24Rik. (PMID: 18352857) 0/0
Adenosine diphosphate phosphate ribose , a specific activator of TRPM2 channel and H(2)O(2), induced inward cation currents that were blocked by ACA. (PMID: 19382906) 0/0
TRPM2 channels, activated by adenosine diphosphoribose and related molecules, are assembled as oligomers and most likely tetramers. (PMID: 17060318) 0/0
Intracellular ADP-ribose is an activator of TRPM2 , which is a Ca2+-permeable channel and mediates H2O2-induced cell death, in the TRPM2-expressing rat beta-cell line RIN-5F. (PMID: 16766853) 0/0
Response to ADP-ribose by activation of TRPM2 in the CRI-G1 insulinoma cell line. (PMID: 12571754) 0/0
Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels. (PMID: 15808509) 0/0
Here, we identify cyclic adenosine diphosphoribose (cADPR) as an agonist of TRPM2 with dual activity: at concentrations above 100 microM, cADPR can gate the channel by itself, whereas lower concentrations of 10 microM have a potentiating effect that enables ADPR to gate the channel at nanomolar concentrations. (PMID: 15808509) 0/0
Endogenous ADPR concentrations in leucocytes are sufficiently high to activate TRPM2 in the presence of an increased [Ca2+]i but probably not at resting [Ca2+]i. (PMID: 17217061) 0/0
TRPM2 is a Ca2+-permeable cation channel that is specifically activated by adenosine diphosphoribose (ADPR). (PMID: 19454650) 0/0
TRPM2 is a Ca2+ -permeable nonselective cation channel activated by intracellular ADP-ribose (ADPR) and by hydrogen peroxide (H2O2). (PMID: 16604090) 0/0
Moreover, patch-clamp recordings from C13 demonstrated that increased intracellular adenosine diphosphoribose (ADPR) or extracellular H2O2 induced an inward current, consistent with activation of TRPM2 . (PMID: 16777714) 0/0
Thus, stimulation of TRPM2 is likely to occur after activation of CD38 (producing ADP-ribose) and during the oxidative burst (enhancing the NAD concentration). (PMID: 12765698) 0/0
Overall, our data are most consistent with a model of oxidative and nitrosative stress-induced TRPM2 activation in which mitochondria are induced to produce free ADP-ribose and release it to the cytosol, where its subsequent accumulation induces TRPM2 gating via interaction within a binding cleft in the C-terminal NUDT9-H domain of TRPM2. (PMID: 15561722) 0/0
These findings suggest that extracellular-added ADP-ribose induces Ca2+ release through the PLC-IP3 pathway and does not act as a TRPM2 activator . (PMID: 16766853) 0/0
Quantification of intracellular cADPr levels and the systematic application of extra- vs. intracellular nucleotides indicate that the outwardly directed gradient rather than the cellular activity of ADPr and cADPr triggers TRPM2 activation , probably along with a simultaneous biotransformation of nucleotides. (PMID: 22219339) 0/0
In the absence of extracellular Ca(2+), a minimum of 30 nM internal Ca(2+) is required to cause partial TRPM2 activation with ADPR. (PMID: 17893195) 0/0