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Subject cui: C0001271 Name: Actins Sem. type: aapp Novel: true


Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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Actins STIMULATES CDC42|CDC42 gene Correct? #Y/N
It is likely that frabin associates with the specific actin and membrane structures and activates Cdc42 and Rac in the vicinity of these structures, eventually leading to morphological changes. (PMID: 11952837) 0/0
One such effector, the Wiskott-Aldrich syndrome protein (WASP), is postulated to link activation of Cdc42 directly to the rearrangement of actin. (PMID: 10360578) 0/0
The cellular stress resulting from the GTP/GDP depletion leads to the activation of the small GTPase Cdc42 and the remodeling of actin, which are crucial events in the transmission of the MPA-mediated necrotic signal. (PMID: 19221465) 0/0
Expression of Dbl homology-pleckstrin homology (DH-PH) region of ITSN-2L (DH-PH(ITSN-2L)) induced specific activation of Cdc42, resulting in formation of extensive filopodia, enhanced cortical actin, as well as a shift from G-actin to F-actin. (PMID: 19622753) 0/0
Our data suggest that Rap1 induces FGD5-dependent Cdc42 activation at cell-cell junctions to locally activate the NM-II through MRCK, thereby inducing CAB formation. (PMID: 24019534) 0/0