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Subject cui: C0813622 Name: Hyaluronan Sem. type: bacs Novel: true

Predicate: INHIBITS

Object cui: C1332712|960 Name: CD44|CD44 gene Sem. type: gngm|gngm Novel: true

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Hyaluronan INHIBITS CD44|CD44 gene Correct? #Y/N
Hyaluronan inhibits prostaglandin E2 production via CD44 in U937 human macrophages. (PMID: 20208419) 0/0
Addition of HA to monocytes decreased the expression of CD44 and induced CL response. (PMID: 11745469) 0/0
Blockade of CD44 with monoclonal antibodies, free HA or CD44 knockdown reduced adhesion and sensitized to lenalidomide. (PMID: 23760401) 0/0
Moreover, chemotaxis towards hyaluronan , but not foetal bovine serum, can be abrogated following treatment of the cells with siRNA oligonucleotides to downregulate CD44 expression. (PMID: 16234326) 0/0
Upon binding to cell surface CD44, proliferation of G1-, but not G3-, overexpressing cells were dose dependently inhibited by exogenous hyaluronan (HA) or HA fragments. (PMID: 14977887) 0/0
Inhibition of CD44, using a blocking antibody, significantly reversed the inhibitory effect of HA on both MMP-13 and p-p38. (PMID: 20706991) 0/0