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Subject cui: C0006979 Name: Carbenoxolone Sem. type: phsu Novel: true

Predicate: INHIBITS

Object cui: C0909868|26206|26871 Name: SPAG8|RNU1-1|11-beta-Hydroxysteroid Dehydrogenase Type 1 Sem. type: gngm|gngm|aapp Novel: true

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Carbenoxolone INHIBITS SPAG8|RNU1-1|11-beta-Hydroxysteroid Dehydrogenase Type 1 Correct? #Y/N
Carbenoxolone inhibited 11beta-HSD1 activity in liver (25 +/- 3 versus 52 +/- 2% conversion in lean; 18 +/- 3 versus 35 +/- 3% in obese; p < 0.01) but not in adipose tissue or skeletal muscle. (PMID: 12649365) 0/0
CBX significantly inhibited 11beta-HSD1 activity in liver and adipose tissue of WNIN/Ob lean and obese rats. (PMID: 23284633) 0/0
In conclusion, carbenoxolone provides a model for liver-specific inhibition of 11beta-HSD1 , which results in improved lipid profile, in Zucker obese rats. (PMID: 12649365) 0/0
Reduction of 7KC was abolished upon inhibition of 11beta-HSD1 by carbenoxolone (CBX) or 2'-hydroxyflavanone. (PMID: 14973125) 0/0
Upon inhibition of 11beta-HSD1 by CBX, 7KC tended to accumulate in the liver, and plasma 7KC concentration increased. (PMID: 14973125) 0/0
Inhibition of 11beta-HSD1 by carbenoxolone was evaluated in liver homogenates obtained from untreated mice. (PMID: 22060140) 0/0
Carbenoxolone inhibition of 11beta-HSD1 in the liver, adipose and brain significantly improves the symptoms of metabolic syndrome in db/db mice. (PMID: 22060140) 0/0
The purpose of the present study was to test the effect of the pharmacological inhibition of 11beta-HSD1 inhibition by carbenoxolone in db/db mice, a genetic model of diabetes. (PMID: 22060140) 0/0
Carbenoxolone (CBX), an 11beta-HSD1 inhibitor , has been shown to reduce IOP in healthy volunteers and patients with ocular hypertension (OHT). (PMID: 19456256) 0/0
Carbenoxolone , a well-known 11beta-HSD1 inhibitor , exhibited an IC(50) value similar to that in in vitro microsomal assay (IC(50) = 0.3 microM). (PMID: 19497289) 0/0
CONCLUSIONS/SIGNIFICANCE: We conclude that 11beta-HSD1 inhibition by CBX decreases obesity and associated co-morbidities in WNIN/Ob obese rats. (PMID: 23284633) 0/0