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Subject cui: C0042172 Name: E-Cadherin Sem. type: aapp Novel: true


Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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E-Cadherin STIMULATES CDC42|CDC42 gene Correct? #Y/N
These data indicate that E-cadherin activates Cdc42 , demonstrating bi-directional interactions between the Rho- and E-cadherin signaling pathways. (PMID: 10950951) 0/0
We found that homophilic engagement of E-cadherin simultaneously activates both Rac1 and Cdc42 . (PMID: 17020937) 0/0
Cdc42 can be activated by E-cadherin in a breast tumour cell line, but the requirement for Cdc42 function for new junction assembly or maintenance has been contradictory. (PMID: 19583567) 0/0
By fusing the Wiskott-Aldrich syndrome protein/GTPase-binding domain to a green fluorescent protein, activation of endogenous Cdc42 by E-cadherin was demonstrated in live cells. (PMID: 10950951) 0/0