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Subject cui: C0007090 Name: Carcinogens Sem. type: hops Novel: true


Object cui: C0020687|3251 Name: HPRT1|Hypoxanthine Phosphoribosyltransferase Sem. type: gngm|aapp Novel: true

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Carcinogens STIMULATES HPRT1|Hypoxanthine Phosphoribosyltransferase Correct? #Y/N
The sequence of this dodecamer, 5'-T(1)A(2)G(3)T(4)C(5)A(6)A(7)G(8)G(9)G(10)C(11)A(12)-3', contains a base (corresponding to A(7)) which is a hot spot for mutagenesis in the hprt gene induced by the carcinogenic (R,S,S,R)-enantiomer of benzo[a]pyrene 7,8-diol 9,10-epoxide, and an adjacent base (corresponding to A(6)) which gave no mutations with this diol epoxide. (PMID: 11123977) 0/0