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Subject cui: C0020196 Name: Hyaluronic Acid Sem. type: bacs Novel: true

Predicate: INHIBITS

Object cui: C1332712|960 Name: CD44|CD44 gene Sem. type: gngm|gngm Novel: true

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Hyaluronic Acid INHIBITS CD44|CD44 gene Correct? #Y/N
These effects were traced to a blockade in complex formation between phosphoinositide 3-kinase (PI3K) and HA receptors and to a transcriptional downregulation of HA receptors, CD44 , and RHAMM, along with PI3K inhibition. (PMID: 21555367) 0/0
Addition of doxorubicin (DOX)-incorporated nanoparticles to tumor cells resulted in the expression of a strong red fluorescence color while they expressed very weak fluorescence when CD44 receptor was blocked with free HA. (PMID: 22001557) 0/0
The internalization of b-sCD44 was blocked by excess unlabeled sCD44, HA, and a 10-mer HA-binding peptide. (PMID: 23287794) 0/0
Incubation of the low metastatic cell line Eb with HA led to a decrease in migration but blocking of CD44 , the principle ligand for HA, by preincubation with an anti-CD44 mAb (KM114), followed by HA exposure increased the locomoting activity significantly. (PMID: 9459209) 0/0
Downregulation of CD44v isoforms of HA9 cells, by CD44v specific antisense inhibited their ability to bind HA, indicating that CD44v, rather than CD44s, is associated with the activation status of this molecule. (PMID: 10757121) 0/0