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Subject cui: C0071163|116|51237 Name: ADCYAP1|MZB1|pituitary adenylate cyclase activating polypeptide Sem. type: gngm|gngm|aapp Novel: true

Predicate: STIMULATES

Object cui: 117|1316|1844|8624 Name: ADCYAP1R1|KLF6|DUSP2|PSMG1 Sem. type: gngm|gngm|gngm|gngm Novel: true

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ADCYAP1|MZB1|pituitary adenylate cyclase activating polypeptide STIMULATES ADCYAP1R1|KLF6|DUSP2|PSMG1 Correct? #Y/N
It has been concluded that in the chick brain, PACAP and cVIP stimulate cAMP biosynthesis via PAC1 and VPAC-type receptors, respectively, and PACAP6-27 seems to be the most potent, yet PACAP/VIP receptor-nonselective antagonist. (PMID: 12794310) 0/0
PACAP and VIP activated distinct PAC1 and VPAC1 receptors, respectively. (PMID: 20699230) 0/0
PACAP, PACAP-specific receptor (PAC1), and the receptors activated by both PACAP and vasoactive intestinal peptide (VIP), VPAC1 and VPAC2, are expressed during embryonic and postnatal development of the rat retina. (PMID: 20646049) 0/0
Pharmacological experiments indicated that PACAP triggers this antiproliferative effect through the activation of both PAC1 and VPACs, and the cAMP-PKA pathway. (PMID: 20646049) 0/0
Fluorescence metry and cAMP assays were both used to detect the functions of the dimerization of PAC1 on the nucleus induced by PACAP. (PMID: 23792266) 0/0
While PACAP27 protected neurons at 1-5 nmol/L, full PAC1 activation by 100 nmol/L PACAP exaggerated hypoxic/ischemic damage. (PMID: 17868305) 0/0