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Subject cui: C0164786|207 Name: AKT1|Proto-Oncogene Proteins c-akt Sem. type: gngm|aapp Novel: true


Object cui: 4233|8731|79811 Name: MET|RNMT|SLTM Sem. type: gngm|gngm|gngm Novel: true

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AKT1|Proto-Oncogene Proteins c-akt STIMULATES MET|RNMT|SLTM Correct? #Y/N
We used chemical inhibitors to test several downstream pathways activated by Met and found that secondary motoneuron development may depend on the p38 and/or Akt pathways. (PMID: 18664287) 0/0
Stimulation with HGF led to activation of Met as well as to activation of PI3-K, PKB/Akt, MEK, and the MAP kinases Erk1 and -2. (PMID: 12379223) 0/0
This effect is accompanied by an increase in c-Met expression and phosphorylation of critical c-Met tyrosine residues without activation of mitogen-activated protein kinase (MAPK) or Akt. (PMID: 21423210) 0/0
High phospho-MET and dependence of the AKT and ERK pathways on MET activation may predict sensitivity to PHA665752, especially in KRAS-mutated cell lines. (PMID: 20736805) 0/0