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Subject cui: 56616 Name: DIABLO Sem. type: gngm Novel: true

Predicate: INHIBITS

Object cui: C0220248|248|961|3375|84061 Name: ALPI|CD47|IAPP|MAGT1|CD47 Antigen Sem. type: gngm|gngm|gngm|gngm|aapp Novel: true

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In short, HtrA2 is a Smac -like inhibitor of IAP activity with a serine protease-dependent cell death-inducing activity. (PMID: 11583623) 0/0
It has been thought that small-molecule mimetics of Smac , an endogenous IAP antagonist , might potentiate apoptosis in cancer cells by promoting caspase activation. (PMID: 18022360) 0/0
Furthermore, the anti-apoptotic role of AREL1-mediated degradation of SMAC , HtrA2, and ARTS was shown by simultaneous knockdown of three IAP antagonists , which caused the inhibition of caspase-3 cleavage, XIAP degradation, and induction of apoptosis. (PMID: 23479728) 0/0