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Subject cui: C0893445 Name: inhibitor-of-apoptosis protein Sem. type: aapp Novel: true

Predicate: INHIBITS

Object cui: C0220248|248|961|3375|84061 Name: ALPI|CD47|IAPP|MAGT1|CD47 Antigen Sem. type: gngm|gngm|gngm|gngm|aapp Novel: true

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inhibitor-of-apoptosis protein INHIBITS ALPI|CD47|IAPP|MAGT1|CD47 Antigen Correct? #Y/N
The choice of the death-mediating caspase pathway in the sympathetic neurons is thus dependent on the regulated relative expression of components of the pathways including those of caspases, IAPs , and IAP inhibitors . (PMID: 11438576) 0/0
Finally, IAPs are attractive therapeutic targets, and efforts are under way to develop antisense and chemical IAP inhibitors that may be useful for the treatment of a variety of malignancies. (PMID: 15492230) 0/0
The inhibitor of apoptosis proteins (IAPs) have recently been shown to modulate nuclear factor kappaB (NF-kappaB) signaling downstream of tumor necrosis factor (TNF) family receptors, positioning them as essential survival factors in several cancer cell lines, as indicated by the cytotoxic activity of several novel small molecule IAP antagonists . (PMID: 20837698) 0/0
The three main factors, IAPs , IAP antagonists , and caspases, are involved in regulating the progress of apoptosis in many species. (PMID: 18401525) 0/0
IAPs can be inhibited by natural antagonists, but a physiological requirement of mammalian IAP antagonists remains to be established. (PMID: 20952537) 0/0