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Subject cui: 2646 Name: GCKR Sem. type: gngm Novel: true

Predicate: STIMULATES

Object cui: C0872265|5601 Name: MAPK9|SAPK Sem. type: gngm|aapp Novel: true

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GCKR STIMULATES MAPK9|SAPK Correct? #Y/N
TRAF2 is a potent activator of a 95-kDa serine/threonine kinase termed germinal center kinase related (GCKR , also referred to as KHS1), which signals activation of the SAPK pathway. (PMID: 10477597) 0/0
Either an oncogenic form of Ras or Bcr-Abl enhances GCKR catalytic activity and its activation of SAPK, whereas inhibition of GCKR impairs Bcr-Abl-induced SAPK activation. (PMID: 9949177) 0/0
Consistent with a role for GCKR in TNF- induced SAPK activation, a kinase-inactive mutant of GCKR is a dominant negative inhibitor of TRAF2-induced SAPK activation. (PMID: 10477597) 0/0