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Subject cui: C0006100 Name: Bradykinin Sem. type: aapp Novel: true

Predicate: STIMULATES

Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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Bradykinin STIMULATES CDC42|CDC42 gene Correct? #Y/N
In cells transfected with IQGAP1deltaGRD, bradykinin was unable to activate Cdc42 , translocate Cdc42 to the membrane fraction, or induce filopodia production. (PMID: 11948177) 0/0
Activation of Cdc42 by applying BDNF or bradykinin mimicked the effect of electrical activity in promoting synaptic maturation. (PMID: 16675395) 0/0
The Cdc42(-/-) cells were defective in filopodia formation stimulated by bradykinin and in dorsal membrane ruffling stimulated by PDGF, whereas the Cdc42GAP(-/-) cells displayed spontaneous filopodia. (PMID: 16914516) 0/0
The inhibitory effect of Z-Asp was blocked by a phosphokinase C activator, PMA, and a Rho activator, lysophosphatidic acid (LPA), while neither a Rac activator, bradykinin , nor a Cdc42 activator , sphingosine-1 -phosphate, was effective. (PMID: 10082131) 0/0