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Subject cui: C0031727 Name: Phosphotransferases Sem. type: aapp Novel: true

Predicate: STIMULATES

Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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Phosphotransferases STIMULATES CDC42|CDC42 gene Correct? #Y/N
A sequential pathway (the JNK pathway) that includes activation of Rac1/Cdc42, mixed lineage kinases, MAP kinase kinases 4 and 7, and JNKs plays a required role in many paradigms of apoptotic cell death. (PMID: 16571722) 0/0
In addition, we showed that p70(S6K) stimulated the rapid activation of both Rac1 and Cdc42, and their downstream effector p21-activated kinase (PAK1), but not RhoA. (PMID: 21258406) 0/0
These results indicate that direct activation of Cdc42 and Rac1 by invasive Salmonella is a prerequisite of Salmonella-mediated death of U937 cells, whereas the simultaneous activation of Akt by tyrosine kinase and PI-3K during receptor-mediated phagocytosis protects cells from apoptosis. (PMID: 12960245) 0/0
We also show that the signaling pathways leading to Rac and Cdc42 activation in HL-60 cells involve G proteins sensitive to pertussis toxin, as well as tyrosine kinase and phosphatidylinositol 3-kinase activities. (PMID: 10224076) 0/0
Moreover, chemokine receptor or beta1 or beta2 integrin engagement on NK cells rapidly resulted in Cdc42 activation and WASp tyrosine phosphorylation as well as in WASp association with Fyn and Pyk-2 tyrosine kinases. (PMID: 20130240) 0/0
Formation of endothelial lumens requires a coordinated PKCepsilon-, Src-, Pak - and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation . (PMID: 19435802) 0/0
The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2. (PMID: 22204307) 0/0