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Subject cui: C0021665 Name: Insulin-Like Growth Factor I Sem. type: aapp Novel: true

Predicate: STIMULATES

Object cui: 5300 Name: PIN1 Sem. type: gngm Novel: true

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Insulin-Like Growth Factor I STIMULATES PIN1 Correct? #Y/N
IGF-1 induces Pin1 expression in promoting cell cycle S-phase entry. (PMID: 11787050) 0/0
Here, we report that Pin1(-/-) MEF cells display a delayed cell cycle S-phase entry in response to IGF stimulation and that IGF-1 induces Pin1 protein expression which correlates with the induction of cyclin D1 and RB phosphorylation in human breast cancer cells. (PMID: 11787050) 0/0
The induction of Pin1 by IGF-1 is mediated via the phosphatidylinositol 3-kinase as well as the MAP kinase pathways. (PMID: 11787050) 0/0
Thus, these data suggest that the mitogenic function of IGF-1 is at least partially linked to the induction of Pin1 , which in turn stimulates cyclin D1 expression and RB phosphorylation, therefore contributing to G0/G1-S transition. (PMID: 11787050) 0/0