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Subject cui: C0079925 Name: Oligonucleotides, Antisense Sem. type: bacs Novel: true

Predicate: INHIBITS

Object cui: C0599933|5970|6857|64689|65125 Name: RELA|SYT1|GORASP1|WNK1|p65 Sem. type: gngm|gngm|gngm|gngm|aapp Novel: true

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Oligonucleotides, Antisense INHIBITS RELA|SYT1|GORASP1|WNK1|p65 Correct? #Y/N
RESULTS: NF-kappaB p65 antisense oligonucleotides resulted in downregulation of NF-kappaB p65 expression, blocked the expression of IL-1beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1beta and IL-8. (PMID: 18996285) 0/0
Specific downregulation of p65 by administration of antisense phosphorothioate oligonucleotides to mice with experimental colitis abrogated clinical and histological signs of mucosal inflammation. (PMID: 9442381) 0/0
Inhibition of either p50 or p65 production with antisense oligonucleotides resulted in a significant downregulation of TNF-alpha-induced CCL27 production. (PMID: 15598438) 0/0
IL-17 stimulated activator protein-1 [AP-1 (c-Fos, c-Jun, and Fra-1)], NF-kappaB (p50 and p65), and CCAAT enhancer-binding protein (C/EBP)-beta DNA binding and reporter gene activities, effects attenuated by antisense oligonucleotides, siRNA-mediated knockdown, or expression of dominant-negative signaling proteins. (PMID: 17921324) 0/0