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Subject cui: C0812239 Name: VAV2 gene Sem. type: gngm Novel: true

Predicate: STIMULATES

Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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VAV2 gene STIMULATES CDC42|CDC42 gene Correct? #Y/N
Vav2 is an activator of Cdc42 , Rac1, and RhoA. (PMID: 10744696) 0/0
Vav2 activates Rac1, Cdc42 , and RhoA downstream from growth factor receptors but not beta1 integrins. (PMID: 10982832) 0/0
Overexpression of constitutively active Vav2 activated Rac1/Cdc42 and reorganized junctional actin cytoskeleton; (PMID: 20940296) 0/0
Inducible expression of a constitutively active form of Vav2 , a Rho GTPase guanine nucleotide exchange factor activated by receptor tyrosine kinases, in three-dimensional MEC culture activated Rac1 and Cdc42 ; (PMID: 19826000) 0/0
These results indicate that the trans-interactions of Necl-5 and nectin-3 and of nectin and nectin induce the activation of Cdc42 and Rac through the common signaling molecules c-Src, Rap1, FRG, and Vav2. (PMID: 16128743) 0/0
Src catalyzes the tyrosine phosphorylation of Vav2 , and overexpression of Vav2 together with activated Src (Src(Y529F)) can completely bypass the need for EGF to promote the activation of Cdc42 . (PMID: 14506284) 0/0
The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2. (PMID: 22204307) 0/0
siRNA and the use of Vav1/2-/- knockout cells further showed that the guanine exchange factor Vav2 is required for Cdc42 activation and maximal bacterial invasion. (PMID: 22204307) 0/0