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Subject cui: 391 Name: RHOG Sem. type: gngm Novel: true

Predicate: STIMULATES

Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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RHOG STIMULATES CDC42|CDC42 gene Correct? #Y/N
These data demonstrate that Trio controls a signaling cascade that activates RhoG , which in turn activates Rac1 and Cdc42Hs . (PMID: 10652265) 0/0
Previous studies suggested that RhoG mediates its effects through activation of Rac1 and Cdc42 . (PMID: 12376551) 0/0
Therefore, our data demonstrate that RhoG controls a pathway that requires the microtubule network and activates Rac1 and Cdc42Hs independently of their growth factor signaling pathways. (PMID: 9614181) 0/0
Constitutively active RhoG proteins produce morphological and cytoskeletal changes similar to those elicited by a simultaneous activation of Rac1 and Cdc42Hs , i.e., the formation of ruffles, lamellipodia, filopodia, and partial loss of stress fibers. (PMID: 9614181) 0/0
Together, these data argue that RhoG function is mediated by signals independent of Rac1 and Cdc42 activation and instead by direct utilization of a subset of common effectors. (PMID: 12376551) 0/0