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Subject cui: C0006469 Name: Butadiene Sem. type: orch Novel: true

Predicate: STIMULATES

Object cui: C1415701|3251 Name: HPRT1|HPRT1 gene Sem. type: gngm|gngm Novel: true

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Butadiene STIMULATES HPRT1|HPRT1 gene Correct? #Y/N
Average exposures to 1-3 parts per million (p.p.m.) of BD were associated with a threefold increase in hprt variant (mutant) frequencies (Vfs). (PMID: 11397407) 0/0
Comparison of induction of hprt mutations by 1,3-butadiene and/or its metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane in lymphocytes from spleen of adult male mice and rats in vivo. (PMID: 9463549) 0/0
Induction of hprt mutations by 1,3-butadiene (BD) and its metabolites 1,2-epoxybutene (EB) and 1,2,3,4-diepoxybutane (DEB) was studied in lymphocytes from spleens of 6- to 14-week-old mice and 10- to 11-week-old rats. (PMID: 9463549) 0/0