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Subject cui: C0527443 Name: bone morphogenetic protein 2 Sem. type: aapp Novel: true

Predicate: STIMULATES

Object cui: 250|470|6590|10850|26033|27295|55226|80150 Name: ALPP|ATHS|SLPI|CCL27|ATRNL1|PDLIM3|NAT10|ASRGL1 Sem. type: gngm|gngm|gngm|gngm|gngm|gngm|gngm|gngm Novel: true

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bone morphogenetic protein 2 STIMULATES ALPP|ATHS|SLPI|CCL27|ATRNL1|PDLIM3|NAT10|ASRGL1 Correct? #Y/N
In cultured osteoblasts from calvariae of COX-2 knockout (-/-) and wild-type (+/+) mice, the absence of COX-2 expression reduced the BMP-2 stimulation of both ALP activity and osteocalcin mRNA expression. (PMID: 12162497) 0/0
Bone morphogenetic protein-2 (BMP-2) induced the ALP expression in pluripotent C3H10T1/2 cells, but it did not increase the transcriptional activity of the promoter region. (PMID: 9584982) 0/0
Both BMP-2 and Tmem119 induced levels of the osteoblast markers Runx2, Osterix, Col1a1, ALP , and osteocalcin, as well as mineralization. (PMID: 24362451) 0/0
Although BMP-2 stimulated both P-eIF2alpha and ATF4 levels, Tmem119 had no effect on P-eIF2alpha but stimulated ATF4 only. (PMID: 24362451) 0/0