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Subject cui: 8826 Name: IQGAP1 Sem. type: gngm Novel: true

Predicate: STIMULATES

Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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IQGAP1 STIMULATES CDC42|CDC42 gene Correct? #Y/N
In addition, the ability of IQGAP1 to increase the amount of active Cdc42 in cells is abrogated upon removal of this region. (PMID: 12745076) 0/0
Transfection of IQGAP1 significantly increased the levels of active, GTP-bound Cdc42 , resulting in the formation of peripheral actin microspikes. (PMID: 11948177) 0/0
Moreover, overexpression of IQGAP1 , but not IQGAP1-DeltaGRD, significantly increased the amount of active Cdc42 in embryonic cells. (PMID: 11584017) 0/0
Moreover, overexpression of IQGAP1, but not IQGAP1 -DeltaGRD, significantly increased the amount of active Cdc42 in embryonic cells. (PMID: 11584017) 0/0
Knockdown of IQGAP1 significantly reduces Salmonella invasion and abrogates activation of Cdc42 and Rac1 by Salmonella. (PMID: 17693642) 0/0
In addition, the ability of IQGAP1 to increase the amount of active Cdc42 in cells is abrogated upon removal of this region. (PMID: 16105843) 0/0
Conversely, IQGAP1 rescues spine deficiency induced by expression of dominant negative Cdc42 by stimulating formation of stubby spines. (PMID: 23441206) 0/0
Lis1 promotes Cdc42 activation through interaction with the calcium sensitive GTPase scaffolding protein IQGAP1, maintaining the perimembrane localization of IQGAP1 and CLIP170 and thereby tethering microtubule ends to the cortical actin cytoskeleton. (PMID: 16369480) 0/0