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Subject cui: C0003241 Name: Antibodies Sem. type: aapp Novel: true

Predicate: INHIBITS

Object cui: C1419337|5649 Name: RELN|RELN gene Sem. type: gngm|gngm Novel: true

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Antibodies INHIBITS RELN|RELN gene Correct? #Y/N
fibronectin degradation is inhibited by inhibitors of serine proteases, and by monoclonal antibody CR-50, an antibody known to block the function of Reelin both in vitro and in vivo. (PMID: 11689558) 0/0
There, inhibition of reelin by blocking with CR-50, an antibody which recognizes the N-terminus of this protein, leads to abnormal development of layer-specific connections. (PMID: 9466431) 0/0
However, rescue of radial glial fiber orientation and granule cell lamination was achieved when reelin was present in the normotopic position provided by wild-type co-culture, an effect that is blocked by the CR-50 antibody against reelin. (PMID: 15459104) 0/0
Accordingly, antibody blockade of reelin function in naive, adult mice induced GCD. (PMID: 19633980) 0/0
Moreover, antibody blockade of Reelin in normal, adult mice resulted in granule cell dispersion. (PMID: 19396394) 0/0