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Subject cui: C0079419|7157 Name: TP53|TP53 gene Sem. type: gngm|gngm Novel: true

Predicate: INHIBITS

Object cui: C1334088|3480 Name: IGF1R|IGF1R gene Sem. type: gngm|gngm Novel: true

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TP53|TP53 gene INHIBITS IGF1R|IGF1R gene Correct? #Y/N
Our results demonstrate that IGF1R is downregulated by P53, and that siRNA targeting of IGF1R increases liver cancer cells sensitivity to adriamycin and promotes apoptosis. (PMID: 17097318) 0/0
One of the challenging questions remaining to be answered is why the wild-type p53 , which per se represses the transcription of the IGF-1R gene , in overexpressed form is necessary for a high IGF-1R expression. (PMID: 12821780) 0/0
Notably, IGF-1R inhibition increases p53 protein stability by reducing p53 ubiquitination and maintains p53 at low levels by decreasing p53 synthesis, thus rendering p53 insensitive to stabilization after DNA damage. (PMID: 17846171) 0/0