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Subject cui: C0073185|6010|29984 Name: RHO|RHOD|rho Sem. type: gngm|gngm|aapp Novel: true

Predicate: STIMULATES

Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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RHO|RHOD|rho STIMULATES CDC42|CDC42 gene Correct? #Y/N
These effects are associated with constitutive activation of both Rac and Cdc42, but not Rho. (PMID: 15897874) 0/0
Therefore, activation of Cdc42 and Rac, as well as inhibition of Rho, helps overcome the CSPG-dependent inhibition of neurite extension. (PMID: 15211597) 0/0
It also results in a shorter duration of activation of Rac/Cdc42 and JNK, which is the negative regulator of myelination, and the earlier activation of Rho and Rho-kinase, which is the positive regulator of myelination. (PMID: 21880919) 0/0
Rho induces the assembly of contractile actin-based microfilaments such as stress fibres, Rac regulates the formation of membrane ruffles and lamellipodia, and Cdc42 activation is necessary for the formation of filopodia. (PMID: 9823474) 0/0
CrGlM21 lost its suppressive effects on Cdc42 activation, whereas CrPrM5 was unable to activate Rho signaling. (PMID: 19286565) 0/0