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Subject cui: C0011777 Name: Dexamethasone Sem. type: phsu Novel: true

Predicate: INHIBITS

Object cui: 9469 Name: CHST3 Sem. type: gngm Novel: true

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Dexamethasone INHIBITS CHST3 Correct? #Y/N
In this paper, we clarified that although pig 3alpha/beta,20beta-HSD is potently inhibited by dexamethasone, glycyrrhetinic acid and spironolactone, this inhibition is remarkably attenuated by deleting the 12 carboxyl-terminal residues. (PMID: 12230123) 0/0
Dexamethasone initially (3-60 min of exposure) decreased the NAD-dependent 11beta-HSD activity to about 60%, which was no longer evident after 2 h or longer. (PMID: 10786827) 0/0
Dexamethasone initially (3-60 min of exposure) decreased the NAD-dependent 11beta-HSD activity to about 60%, which was no longer evident after 2 h or longer. (PMID: 21153064) 0/0
The effect of cortisone but not cortisol or dexamethasone was blocked by an 11beta-HSD inhibitor confirming the functional significance of endogenous cortisol generation. (PMID: 17911392) 0/0