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Subject cui: C0751984 Name: Monomeric GTP-Binding Proteins Sem. type: aapp Novel: true

Predicate: STIMULATES

Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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Monomeric GTP-Binding Proteins STIMULATES CDC42|CDC42 gene Correct? #Y/N
We showed here that Rap1 small G protein was involved in the nectin-induced activation of Cdc42 and formation of AJs. (PMID: 15504743) 0/0
Using a recently developed pull-down assay that specifically captures the active forms of these small GTPases , we found that hypertonicity caused an ~2.5- and ~7.2-fold activation of Rac and Cdc42 , respectively. (PMID: 11788338) 0/0
Gal-1 enhanced the activation of Cdc42, a small GTPase and member of the Rho family, thus increasing the number and length of filopodia on tumor cells. (PMID: 19276182) 0/0
Rather, AVP was found to induce a time-dependent activation of Cdc42, another small GTPase involved in cytoskeletal plasticity. (PMID: 12492427) 0/0
Stellation reversal requires Ca(2+)-dependent activation of Cdc42, a small GTPase known to impact on the cytoskeleton. (PMID: 15089968) 0/0
Inhibition of CD11b/CD18, but not of CD32, the major neutrophil signaling Fc receptor, prevented Streptococcus-induced NADPH oxidase-dependent respiratory burst, and blocking of C3b/iC3b formation inhibited Streptococcus-induced activation of Cdc42, a small GTPase critically involved in transmitting pro-inflammatory signals to the cytoskeleton. (PMID: 15832298) 0/0
Frabin forms filopodia through direct activation of Cdc42 and lamellipodia through indirect activation of Rac small G protein. (PMID: 11527409) 0/0
The trans-interactions of nectins furthermore induce activation of Cdc42 and Rac small G proteins, but the roles of these small G proteins activated in this way remain unknown. (PMID: 14530286) 0/0
Expression of frabin forms filopodia-like microspikes through the direct activation of Cdc42, and lamellipodia through indirect activation of Rac small G protein. (PMID: 11952837) 0/0
Moreover, we demonstrate that activation of both Rac and Cdc42, members of the family of small Rho GTPases, forms the link between the hypotonic stimulation and F-actin reorganization. (PMID: 12788692) 0/0
We have analysed the mechanism of frabin in these two actions and found that frabin induces filopodium-like microspike formation through the direct activation of Cdc42 and lamellipodium-like structure formation through the Cdc42-independent indirect activation of Rac small G protein. (PMID: 10871857) 0/0
The Rho family of small GTPases are activated and required for non-canonical Wnt signaling during gastrulation, and in this chapter, we describe biochemical assays for the detection of Wnt-mediated activation of Rho, Rac, and Cdc42 in both mammalian cells and Xenopus embryo explants. (PMID: 22218897) 0/0