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Subject cui: C1456820 Name: Tumor Necrosis Factor-alpha Sem. type: aapp Novel: true


Object cui: C0872265|5601 Name: MAPK9|SAPK Sem. type: gngm|aapp Novel: true

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Tumor Necrosis Factor-alpha STIMULATES MAPK9|SAPK Correct? #Y/N
Importantly, TNF fails to activate SAPK or NF-kappaB in a human melanoma cell line deficient in Filamin. (PMID: 10617615) 0/0
Since SKK4/MKK7 (but not SKK1/MKK4) is activated by interleukin-1 and tumour necrosis factor in several cells and tissues, we suggest that MEKK1 does not mediate the activation of SKK4/MKK7 and SAPK1/JNK induced by these pro-inflammatory cytokines. (PMID: 9639556) 0/0
We herein investigated the kinase activities of c-Abl and JNK1/SAPK during apoptosis elicited by genotoxic anticancer drugs and tumor necrosis factor (TNF) in U937 cells and their apoptosis-resistant variant UK711 cells. (PMID: 10022809) 0/0