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Subject cui: C0010656 Name: caspase Sem. type: aapp Novel: true

Predicate: INHIBITS

Object cui: C0220248|248|961|3375|84061 Name: ALPI|CD47|IAPP|MAGT1|CD47 Antigen Sem. type: gngm|gngm|gngm|gngm|aapp Novel: true

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caspase INHIBITS ALPI|CD47|IAPP|MAGT1|CD47 Antigen Correct? #Y/N
In contrast, the broad-specificity caspase inhibitor benzyloxycarbonyl-valinyl-alaninyl-aspartyl-(0-methyl)- fluoromethylketone (zVAD-fmk) and the caspase -inhibiting protein X-IAP had no effect on Bax-induced release of Cyt c from mitochondria in vitro but prevented the subsequent activation of caspases in cytosolic extracts. (PMID: 9560217) 0/0
The mechanism underlying the shift is the result of a threefold compensatory elevation of caspase-9 expression and a doubling of levels of direct IAP binding protein with low pI/(DIABLO)/second mitochondria-derived activator of caspase (Smac), an IAP inhibitor , both at the mRNA and protein levels [corrected]. (PMID: 11438576) 0/0
XIAP prevents apoptosis by binding to and inhibiting caspases , and this inhibition can be relieved by IAP antagonists , such as Smac/DIABLO. (PMID: 18022363) 0/0
Here, we will focus on recent data unveiling a link between the proteasome and some elements of the apoptotic machinery including Bcl-2 members, caspases , IAPs and IAP antagonists . (PMID: 16406769) 0/0
Some of them also have a really interesting new gene finger domain, and can prevent cell death by binding and inhibiting active caspases , but are regulated by IAP antagonists . (PMID: 18401525) 0/0
As Smac functions as an endogenous IAP inhibitor , small molecule Smac-mimetics are believed to neutralize IAPs function that results in liberating caspase activity and promoting apoptosis. (PMID: 19966933) 0/0