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Subject cui: C0079925 Name: Oligonucleotides, Antisense Sem. type: bacs Novel: true

Predicate: INHIBITS

Object cui: C1333928|3315 Name: HSPB1|HSPB1 gene Sem. type: gngm|gngm Novel: true

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Oligonucleotides, Antisense INHIBITS HSPB1|HSPB1 gene Correct? #Y/N
Treatment of LNCaP tumor cells in vitro with Hsp27 antisense oligonucleotides (ASO) or short-interfering RNA suppressed Hsp27 levels in a dose-dependent and sequence-specific manner increased the apoptotic sub-G0-G1 fraction and caspase-3 cleavage >2-fold, as well as decreased signal transducers and activators of transcription 3 (Stat3) levels and its downstream genes, c-fos and sPLA-2. (PMID: 16322258) 0/0
Furthermore, several differential proteins including HSP27, HSP70, GRP75 and GRP78 were verified as p53 interacting proteins in NPC by immunoprecipitation and Western blot analysis, and the suppression of HSP27 expression by HSP27 antisense oligonucleotides could decrease the p53 protein level. (PMID: 17184779) 0/0
The suppression of HSP27 expression by HSP27 antisense oligonucleotides could enhance vincristine chemosensitivity in sgc7901/vcr and induce the cells to exhibit apoptotic morphological features after vincristine treatment. (PMID: 16525997) 0/0
Inhibition of HSP27 expression by HSP27 ASOs decreased clonogenic survival and cell viability and increased cell apoptosis of CNE1-IR cells after irradiation, that is, enhanced radiosensitivity of CNE1-IR cells. (PMID: 22847231) 0/0
Inhibition of the expression of Hsp72 and Hsp27 in tumour cells by anti-sense oligonucleotides, enhanced the induction of apoptosis by quercetin. (PMID: 12429348) 0/0