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Subject cui: C0079925 Name: Oligonucleotides, Antisense Sem. type: bacs Novel: true

Predicate: INHIBITS

Object cui: 3303 Name: HSPA1A Sem. type: gngm Novel: true

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Oligonucleotides, Antisense INHIBITS HSPA1A Correct? #Y/N
Hsp72 antisense oligonucleotides blocked Hsp72 production in NIH 3T3 cells in response to mild heat shock and concomitantly abolished the suppressive effect of mild heat shock on UV-induced JNK activation and apoptosis. (PMID: 11157751) 0/0
METHODS: Cardiomyocytes of neonatal rats treated with heat shock (42 degrees C, 30 min, recovery for 6 h) to induce the expression of HSP72 and HSP72 antisense oligonucleotide was transformed to block the expression of HSP72 . (PMID: 16706121) 0/0
The results showed overexpression of Foxa1 promoted the expression of HSP72, while Foxa1 depletion, induced by antisense oligonucleotides , decreased the expression of HSP72 in MCF-7 cells under normal and heat stress condition. (PMID: 19486887) 0/0
Inhibition of the expression of Hsp72 and Hsp27 in tumour cells by anti-sense oligonucleotides, enhanced the induction of apoptosis by quercetin. (PMID: 12429348) 0/0