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Subject cui: C0075193 Name: Staurosporine Sem. type: orch Novel: true

Predicate: INHIBITS

Object cui: C1333928|3315 Name: HSPB1|HSPB1 gene Sem. type: gngm|gngm Novel: true

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Staurosporine INHIBITS HSPB1|HSPB1 gene Correct? #Y/N
Phorbol ester (PMA)-induced dissociation of Hsp27 was completely suppressed by staurosporine, Go 6983, or bisindolylmaleimide I and partially suppressed by SB 203580, or PD 169316 but not by PD 98059 or Uo 126, indicating mediation by 2 cascades. (PMID: 11525238) 0/0
Staurosporine, but not the anti-Fas antibody CH11, abrogates constitutive Hsp70 expression at 37 degrees C and staurosporine also inhibit Hsp27 expression in Jd and Jr cells at 42 degrees C. (PMID: 11282556) 0/0
The PGD(2)-stimulated accumulation of HSP27 was reduced by staurosporine or calphostin C, inhibitors of PKC. (PMID: 11483406) 0/0