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Subject cui: C0017973 Name: Glycosaminoglycans Sem. type: bacs Novel: true

Predicate: STIMULATES

Object cui: 4233|8731|79811 Name: MET|RNMT|SLTM Sem. type: gngm|gngm|gngm Novel: true

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Glycosaminoglycans STIMULATES MET|RNMT|SLTM Correct? #Y/N
HGF activates its specific cellular receptor, c-met, through an aggregation mechanism potentiated by heparan sulfate glycosaminoglycans. (PMID: 9817840) 0/0
As HGF activation of Met is tightly controlled by glycosaminoglycans (GAGs), we tested if GAGs also modulate the Met-InlB interactions. (PMID: 11737639) 0/0
The synthesis of simple, non-sugar glycosaminoglycan (GAG) mimics has been achieved and the analogues evaluated for their ability to inhibit the activation of the MET receptor by hepatocyte growth factor/scatter factor (HGF/SF). (PMID: 17870532) 0/0
The GW domains are shown to be crucial for potentiating Met activation and inducing intracellular invasion, with these effects depending on association between GW domains and glycosaminoglycans. (PMID: 15049825) 0/0
Glycosaminoglycans do not alter the monomeric state of InlB, and are likely to enhance Met activation through a receptor-mediated mode, as opposed to the ligand-mediated mode observed for the LRR fragment. (PMID: 15049825) 0/0