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Subject cui: C0034392 Name: Quercetin Sem. type: orch Novel: true

Predicate: INHIBITS

Object cui: C1333928|3315 Name: HSPB1|HSPB1 gene Sem. type: gngm|gngm Novel: true

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Quercetin INHIBITS HSPB1|HSPB1 gene Correct? #Y/N
On exposure to 100 mM of quercetin , the inhibition of hsp27 and hsp70 expression was observed from 12 hours to 48 hours and 6 hours to 48 hours respectively. (PMID: 11205268) 0/0
In a mouse model of lung cancer, chemotherapy-induced cells increased in the antiapoptosis pathway, and quercetin , an inhibitor of Hsp27 , combined with traditional chemotherapy was effective in blocking the pathway and in the treatment of lung tumors in vivo. (PMID: 21425153) 0/0
Treatment of these cells with quercetin decreased the heat-induced synthesis of hsp27 and hsp70. (PMID: 9367858) 0/0
Quercetin decreased MG132-induced expression of HSP27 , -70, and -90 by more than 70%, and heat shock factors HSF2 and -4 by more than 65%. (PMID: 15914627) 0/0
Quercetin (> or = 50 microM), alone as well as in combination with thermochemotherapy, inhibited the expression of both HSP70 and HSP27 . (PMID: 12926076) 0/0