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Subject cui: C0525037|1029 Name: CDKN2A|CDKN2A gene Sem. type: gngm|gngm Novel: true


Object cui: C0022457|3845 Name: KRAS|K-ras Oncogene Sem. type: gngm|gngm Novel: true

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CDKN2A|CDKN2A gene STIMULATES KRAS|K-ras Oncogene Correct? #Y/N
Multiple combinations of genetic alterations are known to occur in PDAC including mutational activation of KRAS, inactivation of p16/CDKN2A and SMAD4 (DPC4) and dysregulation of PTEN/PI3K/AKT signaling. (PMID: 23316479) 0/0
Therefore, we generated a GPC1 null mouse that combines pancreas-specific Cre-mediated activation of oncogenic Kras (Kras(G12D)) with deletion of a conditional INK4A/Arf allele (Pdx1-Cre;LSL-Kras(G12D);INK4A/Arf(lox/lox);GPC1(-/-) mice). (PMID: 21996748) 0/0
Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt. (PMID: 12359767) 0/0
Here, we assess the cooperative interactions of two signature mutations in mice engineered to sustain pancreas-specific Cre-mediated activation of a mutant Kras allele (KrasG12D) and deletion of a conditional Ink4a/Arf tumor suppressor allele. (PMID: 14681207) 0/0
Additional inactivation of p16 , p53, or transforming growth factor-beta signaling, in the context of Kras activation , dramatically accelerates mPanIN progression to invasive pancreatic ductal adenocarcinoma (PDAC) with abundant stromal expansion and marked fibrosis (desmoplasia). (PMID: 21611096) 0/0