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Subject cui: C0003241 Name: Antibodies Sem. type: aapp Novel: true


Object cui: 4233|8731|79811 Name: MET|RNMT|SLTM Sem. type: gngm|gngm|gngm Novel: true

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Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET. (PMID: 22511956) 0/0
However, when mesangioproliferative glomerulonephritis was induced in rats by the administration of an anti-Thy 1.1 antibody , glomerular HGF expression transiently decreased along with mesangiolysis, and activation of mesangial cells was associated with upregulation of the c-Met receptor. (PMID: 12595276) 0/0
Using the method, we identified an antibody , F46, that binds to human c-Met with high affinity (Kd = 2.56 nM) and specificity, and induces the degradation of c-Met in multiple cancer cells (including MKN45, a gastric cancer cell line) with minimal activation of c-Met signaling. (PMID: 23180291) 0/0