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Subject cui: C0010467 Name: Curcumin Sem. type: orch Novel: true

Predicate: INHIBITS

Object cui: C0599933|5970|6857|64689|65125 Name: RELA|SYT1|GORASP1|WNK1|p65 Sem. type: gngm|gngm|gngm|gngm|aapp Novel: true

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Curcumin INHIBITS RELA|SYT1|GORASP1|WNK1|p65 Correct? #Y/N
AIM: To investigate whether curcumin could attenuate nuclear factor (NF)-kappaB p65 expression and macromolecular leakage in the gastric mucosa of Helicobacter pylori (H. pylori)-infected rats. (PMID: 20731017) 0/0
Curcumin could suppress the expression of NFkappaB p65 . (PMID: 16116955) 0/0
Results from Western blotting showed that curcumin inhibited the protein levels of PKC, FAK, NF-kappaB p65 and Rho A leading to the inhibition of ERK1/2, MKK7, COX-2 and ROCK1, respectively, finally causing the inhibition of MMP-2 and -9 for the inhibition of migration and invasion of N18 cells. (PMID: 20127004) 0/0
CONCLUSION: We found that curcumin decreased the expression of iNOS, p65 , and serum nitric oxide levels, and helped prevent interstitial, glomerular, tubular epithelial, and endothelial cellular injury. (PMID: 18321195) 0/0
Treatment of human myeloid ML-1a cells with tumor necrosis factor (TNF) rapidly activated NF-kappa B, which consists of p50 and p65 subunits, and this activation was inhibited by curcumin. (PMID: 7559628) 0/0