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Subject cui: C0006979 Name: Carbenoxolone Sem. type: phsu Novel: true

Predicate: INHIBITS

Object cui: 9469 Name: CHST3 Sem. type: gngm Novel: true

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Carbenoxolone INHIBITS CHST3 Correct? #Y/N
On CBX treatment, urinary cortisone levels decreased and the cortisol:cortisone ratio increased, indicating that CBX inhibited 11beta-HSD activity that metabolizes cortisol to cortisone. (PMID: 9182864) 0/0
The IC50 of carbenoxolone , a competitive inhibitor of 11beta-HSD , was 75 nM for 7alpha-hydroxycholesterol dehydrogenation and 210 nM for corticosterone dehydrogenation. (PMID: 9632680) 0/0
We examined whether carbenoxolone , a potent inhibitor of 11beta-HSD , would potentiate the inhibitory action of dexamethasone on interleukin-8 release from BEAS-2B cells, and whether prolonged treatment with dexamethasone at therapeutic doses would upregulate 11beta-HSD2 in the cells. (PMID: 12574078) 0/0
Since 11beta-HSD2 has been detected in lung epithelial cells, we examined whether carbenoxolone , a potent inhibitor of 11beta-HSD , would enhance endogenous glucocorticoid action on lung fluid balance and inflammation. (PMID: 15343021) 0/0
Addition of carbenoxolone (10 or 100 microM), a non-specific 11beta-HSD inhibitor , to maternal perfusate decreased conversion capacity from 66.7 to 12.6 or 8.1%, respectively. (PMID: 16338462) 0/0
This effect was dependent upon 11beta-HSD1: these cells solely expressed the type 1 11beta-HSD isozyme (not 11beta-HSD2), and carbenoxolone , an 11beta-HSD inhibitor , prevented the increase in phagocytosis elicited by 11-dehydrocorticosterone. (PMID: 17192572) 0/0
11-dehydrocorticosterone was ineffective in promoting phagocytosis by Hsd11b1(-/-) macrophages, and carbenoxolone , an 11beta-HSD inhibitor , prevented the increase in phagocytosis elicited in wild-type macrophages by 11-dehydrocorticosterone. (PMID: 16751407) 0/0