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Subject cui: C0079189 Name: cytokine Sem. type: aapp Novel: true

Predicate: STIMULATES

Object cui: 4233|8731|79811 Name: MET|RNMT|SLTM Sem. type: gngm|gngm|gngm Novel: true

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cytokine STIMULATES MET|RNMT|SLTM Correct? #Y/N
Using several chimeric constructs consisting of various lengths of the met promoter region fused to the reporter gene of chloramphenicol acetyl transferase (CAT), and by performing transient transfection of these constructs into HepG2 cells, we show that induction of met gene expression by HGF and other cytokines is, at least in part, through up-regulation of met gene promoter activity. (PMID: 9214452) 0/0
Stimulation with cytokines resulted in a two- to threefold increase of c-met expression in vitro. (PMID: 10672841) 0/0
Using several HCC cell lines as a model system, we show that HGF, as well as other cytokines , such as epidermal growth factor (EGF), interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha), induce met and ron expression. (PMID: 9214452) 0/0
Using several chimeric constructs consisting of various lengths of the met promoter region fused to the reporter gene of chloramphenicol acetyl transferase (CAT), and by performing transient transfection of these constructs into HepG2 cells, we show that induction of met gene expression by HGF and other cytokines is, at least in part, through up-regulation of met gene promoter activity. (PMID: 9214452) 0/0