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Subject cui: C0302583 Name: Iron Sem. type: bacs Novel: true

Predicate: INHIBITS

Object cui: C0040679|7018 Name: TF|Transferrin Sem. type: gngm|aapp Novel: true

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Iron INHIBITS TF|Transferrin Correct? #Y/N
These gallium and iron concentrations result in inhibition of transferrin mediated iron uptake in vitro, and in vivo allow for > 90% saturation of transferrin with metal. (PMID: 1337663) 0/0
The goal of this study was to determine if iron suppresses intact endogenous human transferrin synthesis by testing the effects of changes in iron levels on synthesis of transferrin in a human hepatoma cell line HepG2. (PMID: 10772765) 0/0
This indicates that the iron reduced from holo-transferrin at the plasma membrane accounts for at least 50 % of the iron uptake observed. (PMID: 22434419) 0/0
Iron exits the endosome to enter the cytoplasm via the ferrous iron transporter DMT1, a molecule that accepts only Fe(2+), but the reduction potential of ferric iron in free transferrin at endosomal pH (approximately 5.6) is below -500 mV, too low for reduction by physiological agents such as the reduced pyridine nucleotides with reduction potentials of -284 mV. (PMID: 14705946) 0/0
In the original studies which showed the reduction of iron in transferrin by the plasma membranes NADH oxidase, the possible role of the reduction on iron uptake was emphasized. (PMID: 22400117) 0/0