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Subject cui: C0126732 Name: I Kappa B-Alpha Sem. type: aapp Novel: true

Predicate: INHIBITS

Object cui: C0599933|5970|6857|64689|65125 Name: RELA|SYT1|GORASP1|WNK1|p65 Sem. type: gngm|gngm|gngm|gngm|aapp Novel: true

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I Kappa B-Alpha INHIBITS RELA|SYT1|GORASP1|WNK1|p65 Correct? #Y/N
IL-18-mediated PTEN transcription was enhanced by ectopic expression of wild type p65, but inhibited by dominant negative (dn) IkappaB-alpha, dnp65, and dnIKKbeta. (PMID: 16325763) 0/0
ATOR dose-dependently increased the IkappaBalpha expression, decreased the p65 expression in nucleus, and decreased the expression of MCP-1 mRNA and protein (P < 0.05 or P < 0.01). (PMID: 18167242) 0/0
IkappaBalpha is an inhibitor of NF-kappaB and acts by binding and retaining NF-kappaB p65 in the cytoplasm. (PMID: 24361600) 0/0
CONCLUSIONS: Aspirin can attenuate the pathogenesis of atheroma formation, the degradation of IkappaBalpha and pIkappaBalpha, and lower the expression of p65 , indicating that its therapeutic effects on AS may be via inhibition of the UPS. (PMID: 17032134) 0/0
The ankyrin repeat motif identified I kappa B family members, which include I kappa B alpha (pp40/MAD-3 ), I kappa B gamma, and bcl3, directly associated with kappa B site binding proteins, resulting in specific DNA-binding inhibition of rel, p50, or p65 dimers. (PMID: 8268718) 0/0
The diterpene did block TNF-induced ubiquitination, phosphorylation, and degradation of IkappaBalpha , the inhibitor of NF-kappaB and inhibited acetylation of p65 through suppression of binding of p65 to CBP/p300. (PMID: 21820422) 0/0
Ectopic expression of Pokemon in immortalized liver cells HL7702 enhanced p65 and IkappaBalpha expression, whereas silencing of Pokemon in hepatocellular carcinoma cells QGY7703 reduced cellular p65 levels. (PMID: 23054188) 0/0
Furthermore, ApoE(-/-) mice treated with L. acidophilus ATCC 4356 showed an inhibition of translocation of NF-kappaB p65 from cytoplasm to nucleus, suppression of degradation of aortic IkappaB-alpha, and improvements of gut microbiota distribution, as compared to ApoE(-/-) mice in the vehicle group. (PMID: 23747589) 0/0