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Subject cui: C0125575 Name: Leucine-Responsive Regulatory Protein Sem. type: aapp Novel: true

Predicate: INHIBITS

Object cui: 55|5068|8853|10884|10914|11333|11334|50807 Name: ACPP|REG3A|ASAP2|MRPS30|PAPOLA|PDAP1|TUSC2|ASAP1 Sem. type: gngm|gngm|gngm|gngm|gngm|gngm|gngm|gngm Novel: true

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Leucine-Responsive Regulatory Protein INHIBITS ACPP|REG3A|ASAP2|MRPS30|PAPOLA|PDAP1|TUSC2|ASAP1 Correct? #Y/N
A mutational analysis indicates that the binding of Lrp to sites 2 and 3 inhibits pap transcription, which is consistent with the fact that Lrp binding site 3 is located between the --35 and --10 RNA polymerase binding region of papBAp. (PMID: 8846772) 0/0
Our data indicate that the phase OFF state results from repression of the intrinsically active papBA promoter by Lrp and H-NS, each of which can act independently as transcriptional repressors. (PMID: 7494479) 0/0
Lrp is sufficient for the establishment of the phase off pap DNA methylation pattern and repression of pap transcription in vitro. (PMID: 10652304) 0/0