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Subject cui: C0003009 Name: Angiotensin II Sem. type: aapp Novel: true

Predicate: STIMULATES

Object cui: 185 Name: AGTR1 Sem. type: gngm Novel: true

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Angiotensin II STIMULATES AGTR1 Correct? #Y/N
To determine whether AII can induce cardiac hypertrophy directly via myocardial AT1R in the absence of vascular changes, transgenic mice overexpressing the human AT1R under the control of the mouse alpha-myosin heavy chain promoter were generated. (PMID: 10639182) 0/0
As expected, Ang II induced AT1R expression, and stimulated cardiac fibroblast growth and collagen synthesis. (PMID: 22306536) 0/0
Upregulation of proximal tubule AT1R by Ang II may be important in mediating enhanced proximal tubule sodium reabsorption in states of elevated systemic or intrarenal Ang II. (PMID: 7738168) 0/0
Upregulation of proximal tubule AT1R by Ang II may be important in mediating enhanced proximal tubule sodium reabsorption in states of elevated systemic or intrarenal Ang II. (PMID: 7738168) 0/0
Pretreatment with pertussis toxin inhibited Ang II stimulation of AT1R mRNA. (PMID: 7738168) 0/0
This transduction was accompanied by an increase in neuronal firing rate, an effect similar to that observed with angiotensin II stimulation of the neuronal AT1R . (PMID: 12623991) 0/0
Ang II stimulation of the endogenous AT1R increased extracellular signal regulated kinase 1/2 activities. (PMID: 11692164) 0/0
Most of the known pathophysiological effects of Ang II are mediated by AT1R activation . (PMID: 21861069) 0/0