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Subject cui: C0597357 Name: receptor Sem. type: aapp Novel: true

Predicate: STIMULATES

Object cui: 4233|8731|79811 Name: MET|RNMT|SLTM Sem. type: gngm|gngm|gngm Novel: true

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receptor STIMULATES MET|RNMT|SLTM Correct? #Y/N
Both HGF/SF-induced degradation and polyubiquitination of Met were shown to be dependent on the receptor possessing intact tyrosine kinase activity. (PMID: 9001234) 0/0
BACKGROUND: Activation of Met, the receptor for scatter factor/hepatocyte growth factor, is associated with mitogenesis, motogenesis, and decreased cell adhesion. (PMID: 10590366) 0/0
Cell lines with higher levels of c-Met expression and phosphorylation depend on this receptor for survival. (PMID: 22836051) 0/0
Finally, we demonstrate that IGF-1-induced delayed MET activation occurs in multiple cell lines which express both the receptors, suggesting that IGF-1R-mediated MET activation may contribute to tumorigenic properties of multiple cancer types when both growth factor receptors are expressed. (PMID: 23526299) 0/0