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Subject cui: C0285558|207 Name: AKT1|RAC-Alpha Serine/Threonine Kinase Sem. type: gngm|aapp Novel: true


Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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AKT1|RAC-Alpha Serine/Threonine Kinase STIMULATES CDC42|CDC42 gene Correct? #Y/N
Recombinant rac augmented superoxide production, while recombinant CDC42Hs , which shares 70% amino acid sequence identity with rac, did not. (PMID: 8504089) 0/0
The DOCK A and B subfamilies activate Rac , whereas the DOCK D subfamily activates Cdc42 . (PMID: 21613211) 0/0
Recent findings indicate that the carboxyl methylation of Cdc42 is stimulated by only glucose, whereas that of Rap (Kowluru et al., J Clin Invest 98: 540-555, 1996) and Rac (present study) are regulated by glucose or potassium. (PMID: 9464452) 0/0
These findings demonstrate that by serving as a target for GTP bound Cdc42 and a GEF for Rac , Cool-2 mediates a GTPase cascade where the activation of Cdc42 is translated into the activation of Rac. (PMID: 15649357) 0/0
In this study, TUDCA-induced activation of Akt1 is presented to increase cellular levels of pS71-Rac1/Cdc42 in human hepatocarcinoma (HepG2) cells, showing for the first time that bile acid signalling affects the activity of Rho proteins. (PMID: 22628301) 0/0
Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation. (PMID: 10793146) 0/0
Two actions of frabin: direct activation of Cdc42 and indirect activation of Rac. (PMID: 10871857) 0/0
In this study, we show that integrin-induced activation of Cdc42, activation of Rac, cytoskeletal reorganizations, and cell spreading were inhibited in Chinese hamster ovary cells expressing full-length GP Ibalpha compared with GP Ibalpha lacking the 14-3-3 zeta binding site. (PMID: 12810725) 0/0
PAK kinase activity and subcellular distribution are tightly regulated by rapid and transient localized Rac and Cdc42 activation , and by interactions mediated by adapter proteins. (PMID: 15047871) 0/0
Our results indicate that T-lymphoma invasion is driven by Tiam1/Rac or Cdc42 activation , and is dependent on LPA/S1P receptor-mediated RhoA and PLC signaling pathways which lead to pseudopod formation and enhanced infiltration. (PMID: 9670021) 0/0
Fibroblast transformation by Fps/Fes tyrosine kinases requires Ras, Rac , and Cdc42 and induces extracellular signal-regulated and c-Jun N-terminal kinase activation . (PMID: 9593727) 0/0